Biodegradable polymer composites with osteogenic potential
The aim is to study the basic physico-mechanical properties of hydroxyapatite (HA) composites (up to 25–50 wt%) with polylactide (PLA-HA) and poly(e-caprolactone) (PCL-HA) prepared by melt compounding, as well as the osteogenic potential of PLA-HA in vivo.Materials and methods. All biodegradable pol...
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Siberian State Medical University (Tomsk)
2021-01-01
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doaj-1ea8e3591e224468aced4589587a2e8e2021-07-29T08:38:08ZengSiberian State Medical University (Tomsk)Bûlleten' Sibirskoj Mediciny1682-03631819-36842021-01-0119411912910.20538/1682-0363-2020-4-119-1292730Biodegradable polymer composites with osteogenic potentialS. M. Lebedev0D. M. Chistokhin1S. V. Shchadenko2A. N. Dzuman3O. O. Nikolaeva4D. V. Mitrichenko5A. V. Prosolov6I. A. Khlusov7National Research Tomsk Polytechnic UniversityNational Research Tomsk Polytechnic UniversityNational Research Tomsk Polytechnic UniversitySiberian State Medical UniversitySINTEL Research and Production CompanySINTEL Research and Production CompanySINTEL Research and Production CompanyNational Research Tomsk Polytechnic University; Siberian State Medical University; SINTEL Research and Production Company; Immanuel Kant Baltic Federal UniversityThe aim is to study the basic physico-mechanical properties of hydroxyapatite (HA) composites (up to 25–50 wt%) with polylactide (PLA-HA) and poly(e-caprolactone) (PCL-HA) prepared by melt compounding, as well as the osteogenic potential of PLA-HA in vivo.Materials and methods. All biodegradable polymer composites were prepared by hot melt compounding and studied by dielectric spectroscopy in frequency domain, optical microscopy, X-ray diffraction analysis and tensile tests. An ability of PLA-5 wt% HA composites prepared by 3D-printing to induce bone tissue growth in vivo was detected with the help of ectopic subcutaneous test in inbred mice.Results. Values of the real part of complex permittivity of PLA-HA and PCL-HA composites are increased by 15–30% compared to those for initial PLA and PCL, while tand loss factor does not exceed 0.02 for PLA-based composites and 0.2 for PCL-based composites. The crystallinity degree of PLA-HA composites is increased by 3 and 6 times with an increase of HA content from 25 to 50 wt% respectively compared to the indicator for PLA. The crystallinity degree of PCL-HA composites with 25 wt% HA is increased by 2 times compared to the value for PCL. It is due to the fact that HA powder particles play the role of additional nucleation centers. For all this, mechanical strength of composites diminished statistically. Even lowest HA content (5 wt%) in PLA-HA composites prepared by 3D-printing increased the incidence of ectopic osteogenesis by 40%.Conclusion. Designed biodegradable composites have a potential of practical use for bone tissue engineering.https://bulletin.tomsk.ru/jour/article/view/4159poly(lactic acid)poly(e-caprolactone)hydroxyapatitemelt compoundingphysicochemical propertiesectopic osteogenesisin vivo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. M. Lebedev D. M. Chistokhin S. V. Shchadenko A. N. Dzuman O. O. Nikolaeva D. V. Mitrichenko A. V. Prosolov I. A. Khlusov |
spellingShingle |
S. M. Lebedev D. M. Chistokhin S. V. Shchadenko A. N. Dzuman O. O. Nikolaeva D. V. Mitrichenko A. V. Prosolov I. A. Khlusov Biodegradable polymer composites with osteogenic potential Bûlleten' Sibirskoj Mediciny poly(lactic acid) poly(e-caprolactone) hydroxyapatite melt compounding physicochemical properties ectopic osteogenesis in vivo |
author_facet |
S. M. Lebedev D. M. Chistokhin S. V. Shchadenko A. N. Dzuman O. O. Nikolaeva D. V. Mitrichenko A. V. Prosolov I. A. Khlusov |
author_sort |
S. M. Lebedev |
title |
Biodegradable polymer composites with osteogenic potential |
title_short |
Biodegradable polymer composites with osteogenic potential |
title_full |
Biodegradable polymer composites with osteogenic potential |
title_fullStr |
Biodegradable polymer composites with osteogenic potential |
title_full_unstemmed |
Biodegradable polymer composites with osteogenic potential |
title_sort |
biodegradable polymer composites with osteogenic potential |
publisher |
Siberian State Medical University (Tomsk) |
series |
Bûlleten' Sibirskoj Mediciny |
issn |
1682-0363 1819-3684 |
publishDate |
2021-01-01 |
description |
The aim is to study the basic physico-mechanical properties of hydroxyapatite (HA) composites (up to 25–50 wt%) with polylactide (PLA-HA) and poly(e-caprolactone) (PCL-HA) prepared by melt compounding, as well as the osteogenic potential of PLA-HA in vivo.Materials and methods. All biodegradable polymer composites were prepared by hot melt compounding and studied by dielectric spectroscopy in frequency domain, optical microscopy, X-ray diffraction analysis and tensile tests. An ability of PLA-5 wt% HA composites prepared by 3D-printing to induce bone tissue growth in vivo was detected with the help of ectopic subcutaneous test in inbred mice.Results. Values of the real part of complex permittivity of PLA-HA and PCL-HA composites are increased by 15–30% compared to those for initial PLA and PCL, while tand loss factor does not exceed 0.02 for PLA-based composites and 0.2 for PCL-based composites. The crystallinity degree of PLA-HA composites is increased by 3 and 6 times with an increase of HA content from 25 to 50 wt% respectively compared to the indicator for PLA. The crystallinity degree of PCL-HA composites with 25 wt% HA is increased by 2 times compared to the value for PCL. It is due to the fact that HA powder particles play the role of additional nucleation centers. For all this, mechanical strength of composites diminished statistically. Even lowest HA content (5 wt%) in PLA-HA composites prepared by 3D-printing increased the incidence of ectopic osteogenesis by 40%.Conclusion. Designed biodegradable composites have a potential of practical use for bone tissue engineering. |
topic |
poly(lactic acid) poly(e-caprolactone) hydroxyapatite melt compounding physicochemical properties ectopic osteogenesis in vivo |
url |
https://bulletin.tomsk.ru/jour/article/view/4159 |
work_keys_str_mv |
AT smlebedev biodegradablepolymercompositeswithosteogenicpotential AT dmchistokhin biodegradablepolymercompositeswithosteogenicpotential AT svshchadenko biodegradablepolymercompositeswithosteogenicpotential AT andzuman biodegradablepolymercompositeswithosteogenicpotential AT oonikolaeva biodegradablepolymercompositeswithosteogenicpotential AT dvmitrichenko biodegradablepolymercompositeswithosteogenicpotential AT avprosolov biodegradablepolymercompositeswithosteogenicpotential AT iakhlusov biodegradablepolymercompositeswithosteogenicpotential |
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1721253214273142784 |