Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis
Jun-Li Ma,1 Yan Zhao,1 Chen-Yang Guo,1 Hong-Tao Hu,1 Lin Zheng,1 Er-Jiang Zhao,2 Hai-Liang Li1 1Department of Radiology Intervention, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450003, China; 2Department of Epidemiology and Biostatistics, Affiliated Tumor Hospital of Zhengzhou Univ...
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doaj-1eaab6aa9c8c4206b59ae71525ed6a342020-11-24T20:50:50ZengDove Medical PressCancer Management and Research1179-13222018-11-01Volume 105395541042047Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysisMa JLZhao YGuo CYHu HTZheng LZhao EJLi HLJun-Li Ma,1 Yan Zhao,1 Chen-Yang Guo,1 Hong-Tao Hu,1 Lin Zheng,1 Er-Jiang Zhao,2 Hai-Liang Li1 1Department of Radiology Intervention, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450003, China; 2Department of Epidemiology and Biostatistics, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450003, China Background: Several epidemiology studies have explored the association between dietary B vitamins’ intake and the risk of esophageal cancer (EC). However, the results remain inconclusive. Thus, we conducted a systematic review with meta-analysis to evaluate such association. Methods: Literature retrieval was performed using PubMed (Medline), ScienceDirect, and Cochrane Library electronic databases for all studies published from database inception to December 2017. Results: The meta-analysis included 19 studies and showed an overall decreased risk of EC (OR=0.77, 95% CI: 0.68–0.87) in association with multivitamin B (ie, B1, B2, B3, B5, B6, B9, and B12) dietary intake. In a subgroup analysis based on vitamin B subclass, B1, B3, B6, and B9 vitamins were associated with decreased EC risk (vitamin B1: OR=0.68, 95% CI: 0.56–0.82; vitamin B3: OR=0.70, 95% CI: 0.53–0.94; vitamin B6: OR=0.64, 95% CI: 0.49–0.83; and vitamin B9: OR=0.69, 95% CI: 0.55–0.86). By contrast, no association was detected between dietary vitamin B2 and vitamin B5 intake and EC risk (vitamin B2: OR=0.86, 95% CI: 0.64–1.16; vitamin B5: OR=0.49, 95% CI: 0.20–1.20), whereas a potential non-linear dose–response association was found between dietary vitamin B12 intake and EC risk. A statistically significant, inverse association was observed for an increase of 100 µg/day in supplemental vitamin B6 and B9 and EC risk (vitamin B6: OR=0.98, 95% CI: 0.98–0.99; vitamin B9: OR= 0.89; 95% CI: 0.86–0.94). Conclusion: These findings support that vitamin B may have an influence on carcinogenesis of the esophagus. Vitamin B1, B3, B6, B9 showed a decreased risk of EC, and vitamin B12 showed an increased risk of EC. Keywords: B vitamins, esophageal cancer, meta-analysishttps://www.dovepress.com/dietary-vitamin-b-intake-and-the-risk-of-esophageal-cancer-a-meta-anal-peer-reviewed-article-CMARB vitaminsesophageal cancerMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ma JL Zhao Y Guo CY Hu HT Zheng L Zhao EJ Li HL |
spellingShingle |
Ma JL Zhao Y Guo CY Hu HT Zheng L Zhao EJ Li HL Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis Cancer Management and Research B vitamins esophageal cancer Meta-analysis |
author_facet |
Ma JL Zhao Y Guo CY Hu HT Zheng L Zhao EJ Li HL |
author_sort |
Ma JL |
title |
Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis |
title_short |
Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis |
title_full |
Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis |
title_fullStr |
Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis |
title_full_unstemmed |
Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis |
title_sort |
dietary vitamin b intake and the risk of esophageal cancer: a meta-analysis |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2018-11-01 |
description |
Jun-Li Ma,1 Yan Zhao,1 Chen-Yang Guo,1 Hong-Tao Hu,1 Lin Zheng,1 Er-Jiang Zhao,2 Hai-Liang Li1 1Department of Radiology Intervention, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450003, China; 2Department of Epidemiology and Biostatistics, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450003, China Background: Several epidemiology studies have explored the association between dietary B vitamins’ intake and the risk of esophageal cancer (EC). However, the results remain inconclusive. Thus, we conducted a systematic review with meta-analysis to evaluate such association. Methods: Literature retrieval was performed using PubMed (Medline), ScienceDirect, and Cochrane Library electronic databases for all studies published from database inception to December 2017. Results: The meta-analysis included 19 studies and showed an overall decreased risk of EC (OR=0.77, 95% CI: 0.68–0.87) in association with multivitamin B (ie, B1, B2, B3, B5, B6, B9, and B12) dietary intake. In a subgroup analysis based on vitamin B subclass, B1, B3, B6, and B9 vitamins were associated with decreased EC risk (vitamin B1: OR=0.68, 95% CI: 0.56–0.82; vitamin B3: OR=0.70, 95% CI: 0.53–0.94; vitamin B6: OR=0.64, 95% CI: 0.49–0.83; and vitamin B9: OR=0.69, 95% CI: 0.55–0.86). By contrast, no association was detected between dietary vitamin B2 and vitamin B5 intake and EC risk (vitamin B2: OR=0.86, 95% CI: 0.64–1.16; vitamin B5: OR=0.49, 95% CI: 0.20–1.20), whereas a potential non-linear dose–response association was found between dietary vitamin B12 intake and EC risk. A statistically significant, inverse association was observed for an increase of 100 µg/day in supplemental vitamin B6 and B9 and EC risk (vitamin B6: OR=0.98, 95% CI: 0.98–0.99; vitamin B9: OR= 0.89; 95% CI: 0.86–0.94). Conclusion: These findings support that vitamin B may have an influence on carcinogenesis of the esophagus. Vitamin B1, B3, B6, B9 showed a decreased risk of EC, and vitamin B12 showed an increased risk of EC. Keywords: B vitamins, esophageal cancer, meta-analysis |
topic |
B vitamins esophageal cancer Meta-analysis |
url |
https://www.dovepress.com/dietary-vitamin-b-intake-and-the-risk-of-esophageal-cancer-a-meta-anal-peer-reviewed-article-CMAR |
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