Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice
Lumefantrine and trimethoprim are antimalarial and antibiotic drugs respectively. Even though, therapeutic agents have shown enhanced efficacy upon coordination to metal ion, antimalarial activity of lumefantrine-trimethoprim-copper complex drug has not been reported. This study evaluated the anti-m...
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Faculty of Science, University of Peradeniya, Sri Lanka
2018-12-01
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doaj-1eabd5d6ad3a4638840f05c6594cb56c2021-09-20T15:23:30ZengFaculty of Science, University of Peradeniya, Sri LankaCeylon Journal of Science2513-28142513-230X2018-12-0147434735610.4038/cjs.v47i4.75525730Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in miceR.O. Arise0A. Olowo1M.A. Acho2O. Olufemi3A.A. Adewale4A.C. Tella5University of IlorinUniversity of IlorinUniversity of IlorinUniversity of IlorinBowen UniversityUniversity of IlorinLumefantrine and trimethoprim are antimalarial and antibiotic drugs respectively. Even though, therapeutic agents have shown enhanced efficacy upon coordination to metal ion, antimalarial activity of lumefantrine-trimethoprim-copper complex drug has not been reported. This study evaluated the anti-malarial potency and safety of synthesized lumefantrine-trimethoprim-copper (LTC) complex in mice. A total of 35 albino mice were randomly divided into seven groups. Mice in groups 1 and 7 were not infected with <em>Plasmodium</em> <em>berghei</em>. Infected mice in groups 3, 4, 5, and 6 were treated with chloroquine, LTC, trimethoprim and lumefantrine respectively. All the animals were sacrificed 24 hours after completion of their doses. Percentage parasitaemia, chemo suppression attained in the group of mice infected, but treated with LTC (96.84%) or chloroquine (97.80%)was higher than those treated with lumefantrine (75.79%) or trimethoprim (76.84%) at day 8 post-inoculation, when compared with control. There was significant reduction in the activities of ALP, ALT and AST in the liver of treated mice when compared with control. Increased chromosomal aberration was observed in all treated groups when compared with control.The observed modifications in the biochemical indices and the presence of chromosomal aberrations in the organs studied, suggested a selective and functional toxicity of the drug.https://cjs.sljol.info/articles/7552lumefantrine-trimethoprim-copperltcantimalarialefficacysafety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
R.O. Arise A. Olowo M.A. Acho O. Olufemi A.A. Adewale A.C. Tella |
spellingShingle |
R.O. Arise A. Olowo M.A. Acho O. Olufemi A.A. Adewale A.C. Tella Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice Ceylon Journal of Science lumefantrine-trimethoprim-copper ltc antimalarial efficacy safety |
author_facet |
R.O. Arise A. Olowo M.A. Acho O. Olufemi A.A. Adewale A.C. Tella |
author_sort |
R.O. Arise |
title |
Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice |
title_short |
Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice |
title_full |
Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice |
title_fullStr |
Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice |
title_full_unstemmed |
Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice |
title_sort |
efficacy and safety properties of lumefantrine-trimethoprim-copper complex in mice |
publisher |
Faculty of Science, University of Peradeniya, Sri Lanka |
series |
Ceylon Journal of Science |
issn |
2513-2814 2513-230X |
publishDate |
2018-12-01 |
description |
Lumefantrine and trimethoprim are antimalarial and antibiotic drugs respectively. Even though, therapeutic agents have shown enhanced efficacy upon coordination to metal ion, antimalarial activity of lumefantrine-trimethoprim-copper complex drug has not been reported. This study evaluated the anti-malarial potency and safety of synthesized lumefantrine-trimethoprim-copper (LTC) complex in mice. A total of 35 albino mice were randomly divided into seven groups. Mice in groups 1 and 7 were not infected with <em>Plasmodium</em> <em>berghei</em>. Infected mice in groups 3, 4, 5, and 6 were treated with chloroquine, LTC, trimethoprim and lumefantrine respectively. All the animals were sacrificed 24 hours after completion of their doses. Percentage parasitaemia, chemo suppression attained in the group of mice infected, but treated with LTC (96.84%) or chloroquine (97.80%)was higher than those treated with lumefantrine (75.79%) or trimethoprim (76.84%) at day 8 post-inoculation, when compared with control. There was significant reduction in the activities of ALP, ALT and AST in the liver of treated mice when compared with control. Increased chromosomal aberration was observed in all treated groups when compared with control.The observed modifications in the biochemical indices and the presence of chromosomal aberrations in the organs studied, suggested a selective and functional toxicity of the drug. |
topic |
lumefantrine-trimethoprim-copper ltc antimalarial efficacy safety |
url |
https://cjs.sljol.info/articles/7552 |
work_keys_str_mv |
AT roarise efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice AT aolowo efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice AT maacho efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice AT oolufemi efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice AT aaadewale efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice AT actella efficacyandsafetypropertiesoflumefantrinetrimethoprimcoppercomplexinmice |
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