Organisation and functional role of the brain angiotensin system
The discovery that all components of the renin-angiotensin system (RAS) are present in the brain led investigators to postulate the existence of a local brain RAS. Supporting this, angiotensin immunoreactive neurones have been visualised in the brain. Two major pathways were described: a forebrain p...
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doaj-1ead0d5e46ab46d48c4cd7588c5d0d0a2021-05-02T20:27:55ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762002-03-0131_suppl394810.3317/JRAAS.2002.02910.3317_JRAAS.2002.029Organisation and functional role of the brain angiotensin systemCatherine Llorens-CortesFrederic Ao MendelsohnThe discovery that all components of the renin-angiotensin system (RAS) are present in the brain led investigators to postulate the existence of a local brain RAS. Supporting this, angiotensin immunoreactive neurones have been visualised in the brain. Two major pathways were described: a forebrain pathway which connects circumventricular organs to the median preoptic nucleus, paraventricular and supraoptic nuclei, and a second pathway connecting the hypothalamus to the medulla oblongata. Blood-brain-barrier deficient circumventricular organs are rich in angiotensin II (Ang II) receptors. By activating these receptors, circulating Ang II may act on central cardiovascular centres via angiotensinergic neurones, providing a link between peripheral and central Ang II systems. Among the effector peptides of the brain RAS, Ang II and angiotensin III (Ang III) have the same affinity for type 1 and type 2 Ang II receptors. When injected into the brain, both peptides increase blood pressure (BP), water intake and pituitary hormone release and may modify learning and memory. Since Ang II is converted in vivo to Ang III, the nature of the true effector is unknown. This review summarises new insights into the predominant role of brain Ang III in the control of BP and underlines the fact that brain aminopeptidase A, the enzyme forming central Ang III, could constitute a putative central therapeutic target for the treatment of hypertension.http://jra.sagepub.com/content/3/1_suppl/39.full.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Catherine Llorens-Cortes Frederic Ao Mendelsohn |
spellingShingle |
Catherine Llorens-Cortes Frederic Ao Mendelsohn Organisation and functional role of the brain angiotensin system Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Catherine Llorens-Cortes Frederic Ao Mendelsohn |
author_sort |
Catherine Llorens-Cortes |
title |
Organisation and functional role of the brain angiotensin system |
title_short |
Organisation and functional role of the brain angiotensin system |
title_full |
Organisation and functional role of the brain angiotensin system |
title_fullStr |
Organisation and functional role of the brain angiotensin system |
title_full_unstemmed |
Organisation and functional role of the brain angiotensin system |
title_sort |
organisation and functional role of the brain angiotensin system |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2002-03-01 |
description |
The discovery that all components of the renin-angiotensin system (RAS) are present in the brain led investigators to postulate the existence of a local brain RAS. Supporting this, angiotensin immunoreactive neurones have been visualised in the brain. Two major pathways were described: a forebrain pathway which connects circumventricular organs to the median preoptic nucleus, paraventricular and supraoptic nuclei, and a second pathway connecting the hypothalamus to the medulla oblongata. Blood-brain-barrier deficient circumventricular organs are rich in angiotensin II (Ang II) receptors. By activating these receptors, circulating Ang II may act on central cardiovascular centres via angiotensinergic neurones, providing a link between peripheral and central Ang II systems. Among the effector peptides of the brain RAS, Ang II and angiotensin III (Ang III) have the same affinity for type 1 and type 2 Ang II receptors. When injected into the brain, both peptides increase blood pressure (BP), water intake and pituitary hormone release and may modify learning and memory. Since Ang II is converted in vivo to Ang III, the nature of the true effector is unknown. This review summarises new insights into the predominant role of brain Ang III in the control of BP and underlines the fact that brain aminopeptidase A, the enzyme forming central Ang III, could constitute a putative central therapeutic target for the treatment of hypertension. |
url |
http://jra.sagepub.com/content/3/1_suppl/39.full.pdf |
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