Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population
<b>AIM:</b>To assess the association between age-related macular degeneration (AMD) and three single nucleotide polymorphisms (SNPs) related to the vascular endothelial growth factor (VEGF) gene.<b>METHODS:</b> The patients who were diagnosed with AMD were included in this pr...
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doaj-1ebcf5aece6a480a93f550c515c30ff82020-11-24T22:51:23ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-10-017577377710.3980/j.issn.2222-3959.2014.05.06Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish populationYunus Bulgu0Gokhan Ozan Cetin1Vildan Caner2Ebru Nevin Cetin3Volkan Yaylali4Cem Yildirim5Department of Ophthalmology, School of Medicine, Pamukkale University, Denizli 20070, TurkeyDepartment of Medical Genetics, School of Medicine, Pamukkale University, Denizli 20070, TurkeyDepartment of Medical Biology, School of Medicine, Pamukkale University, Denizli 20070, TurkeyDepartment of Ophthalmology, School of Medicine, Pamukkale University, Denizli 20070, TurkeyDepartment of Ophthalmology, School of Medicine, Pamukkale University, Denizli 20070, TurkeyDepartment of Ophthalmology, School of Medicine, Pamukkale University, Denizli 20070, Turkey<b>AIM:</b>To assess the association between age-related macular degeneration (AMD) and three single nucleotide polymorphisms (SNPs) related to the vascular endothelial growth factor (VEGF) gene.<b>METHODS:</b> The patients who were diagnosed with AMD were included in this prospective study. Three SNPs (rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 controls.<b>RESULTS:</b> The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group (<i>P=</i>0.072 and <i>P=</i>0.058). However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type AMD (<i>P=</i>0.005 and <i>P=</i>0.010, respectively). One of the SNPs (rs1413711) was also found to be associated with the severity of AMD (<i>P=</i>0.001) with significant genotype distribution between early, intermediate, and advanced stages of the disease. The ancestral alleles were protective for both SNPs while the polymorphic alleles increased the risk for dry AMD.<b>CONCLUSION:</b> VEGF SNPs rs1413711 and rs2146323 polymorphisms are significantly associated with AMD subtypes in our population.http://www.ijo.cn/en_publish/2014/5/20140506.pdfage-related macular degenerationvascular endothelial growth factorsingle nucleotide polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunus Bulgu Gokhan Ozan Cetin Vildan Caner Ebru Nevin Cetin Volkan Yaylali Cem Yildirim |
spellingShingle |
Yunus Bulgu Gokhan Ozan Cetin Vildan Caner Ebru Nevin Cetin Volkan Yaylali Cem Yildirim Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population International Journal of Ophthalmology age-related macular degeneration vascular endothelial growth factor single nucleotide polymorphism |
author_facet |
Yunus Bulgu Gokhan Ozan Cetin Vildan Caner Ebru Nevin Cetin Volkan Yaylali Cem Yildirim |
author_sort |
Yunus Bulgu |
title |
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population |
title_short |
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population |
title_full |
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population |
title_fullStr |
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population |
title_full_unstemmed |
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population |
title_sort |
vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a turkish population |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2014-10-01 |
description |
<b>AIM:</b>To assess the association between age-related macular degeneration (AMD) and three single nucleotide polymorphisms (SNPs) related to the vascular endothelial growth factor (VEGF) gene.<b>METHODS:</b> The patients who were diagnosed with AMD were included in this prospective study. Three SNPs (rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 controls.<b>RESULTS:</b> The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group (<i>P=</i>0.072 and <i>P=</i>0.058). However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type AMD (<i>P=</i>0.005 and <i>P=</i>0.010, respectively). One of the SNPs (rs1413711) was also found to be associated with the severity of AMD (<i>P=</i>0.001) with significant genotype distribution between early, intermediate, and advanced stages of the disease. The ancestral alleles were protective for both SNPs while the polymorphic alleles increased the risk for dry AMD.<b>CONCLUSION:</b> VEGF SNPs rs1413711 and rs2146323 polymorphisms are significantly associated with AMD subtypes in our population. |
topic |
age-related macular degeneration vascular endothelial growth factor single nucleotide polymorphism |
url |
http://www.ijo.cn/en_publish/2014/5/20140506.pdf |
work_keys_str_mv |
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