Mining predicted essential genes of Brugia malayi for nematode drug targets.
We report results from the first genome-wide application of a rational drug target selection methodology to a metazoan pathogen genome, the completed draft sequence of Brugia malayi, a parasitic nematode responsible for human lymphatic filariasis. More than 1.5 billion people worldwide are at risk o...
Main Authors: | Sanjay Kumar, Kshitiz Chaudhary, Jeremy M Foster, Jacopo F Novelli, Yinhua Zhang, Shiliang Wang, David Spiro, Elodie Ghedin, Clotilde K S Carlow |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-11-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0001189 |
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