MiR-15a regulates bicuspid aortic valve calcification via TGF-β signaling pathway via inhibiting Smad7

MiR-15a regulates bicuspid aortic valve calcification via TGF-β signaling pathway via inhibiting Smad7

Background: Bicuspid aortic valve is a heritable heart valve disease with characteristic early onset of valve calcification and stenosis with rapid progression compared with tricuspid aortic valve. Strong evidence indicates that many miRNAs and their target genes are involved in the development of B...

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Bibliographic Details
Main Authors: Jiankang Xu, Hao Liu, Rui Zheng, Minyan Dang, Yongfeng Shao, Junjie Du
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of King Saud University: Science
Subjects:
Bicuspid aortic valve
Calcification
miR-15a
Smad7
Runx2
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364720303918

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