Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients
Abstract Objective The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism. Unregulated levels of IGFs/IGFBPs have been associated with the development of glucose intolerance and metabolic syndrome...
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doaj-1eda2dd01a11433bb64e422a63de287b2020-11-25T02:45:43ZengBMCBMC Research Notes1756-05002019-10-011211510.1186/s13104-019-4492-9Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patientsSomayeh Pouriamehr0Haleh Barmaki1Mozhdeh Rastegary2Farzaneh Lotfi3Mohsen Nabi Afjadi4Department of Biology, Dezful Branch, Islamic Azad UniversityDepartment of Laboratory Medicine, Faculty of Para Medical Sciences, Shahid Behest University of Medical SciencesDepartment of Biology, Basic Science Faculty, Shahrekord Branch, Islamic Azad UniversityDepartment of Clinical Biochemistry, Faculty of Medicine, Kermanshah University of Medical SciencesInstitute of Biochemistry and BiophysicsAbstract Objective The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism. Unregulated levels of IGFs/IGFBPs have been associated with the development of glucose intolerance and metabolic syndrome X (MSx). We hypothesized that change of IGFs/IGFBPs levels could increase the risk of MSx; thus, this study aimed to evaluate the serostatus of IGFs/IGFBPs in individuals with MSx. Results After adjustment for metabolic parameters, MSx patients had a lower level of IGF-1, IGFBP-1, and IGFBP-2 compared with subjects in the control group. Further analysis revealed a positive correlation between serum levels of IGF-1 and IGF-2 (p < 0.05), as well as serum IGFBP-3 and IGF-2 (p < 0.05). Also, the statistical analysis showed a negative association of serum IGF-1 with plasma glucose and total cholesterol levels (p < 0.05). Besides, a negative relationship was found between serum concentrations of IGF-1/IGF-2 and the risk of developing MSx. These data indicated that some components of IGFs/IGFBPs are linked with the pathogenesis of MSx. In conclusion, these inverse associations showed a possible linkage between the IGF/IGFBP signaling pathway and the development of MSx. It seems the decreased concentrations of IGFs edmay be regarded as a potential biomarker for early diagnosis or even prognosis of MSx but need more systematic studies to confirmed it.http://link.springer.com/article/10.1186/s13104-019-4492-9Metabolic syndrome XInsulin-like growth factorInsulin-like growth factor receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Somayeh Pouriamehr Haleh Barmaki Mozhdeh Rastegary Farzaneh Lotfi Mohsen Nabi Afjadi |
spellingShingle |
Somayeh Pouriamehr Haleh Barmaki Mozhdeh Rastegary Farzaneh Lotfi Mohsen Nabi Afjadi Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients BMC Research Notes Metabolic syndrome X Insulin-like growth factor Insulin-like growth factor receptor |
author_facet |
Somayeh Pouriamehr Haleh Barmaki Mozhdeh Rastegary Farzaneh Lotfi Mohsen Nabi Afjadi |
author_sort |
Somayeh Pouriamehr |
title |
Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
title_short |
Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
title_full |
Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
title_fullStr |
Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
title_full_unstemmed |
Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
title_sort |
investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2019-10-01 |
description |
Abstract Objective The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism. Unregulated levels of IGFs/IGFBPs have been associated with the development of glucose intolerance and metabolic syndrome X (MSx). We hypothesized that change of IGFs/IGFBPs levels could increase the risk of MSx; thus, this study aimed to evaluate the serostatus of IGFs/IGFBPs in individuals with MSx. Results After adjustment for metabolic parameters, MSx patients had a lower level of IGF-1, IGFBP-1, and IGFBP-2 compared with subjects in the control group. Further analysis revealed a positive correlation between serum levels of IGF-1 and IGF-2 (p < 0.05), as well as serum IGFBP-3 and IGF-2 (p < 0.05). Also, the statistical analysis showed a negative association of serum IGF-1 with plasma glucose and total cholesterol levels (p < 0.05). Besides, a negative relationship was found between serum concentrations of IGF-1/IGF-2 and the risk of developing MSx. These data indicated that some components of IGFs/IGFBPs are linked with the pathogenesis of MSx. In conclusion, these inverse associations showed a possible linkage between the IGF/IGFBP signaling pathway and the development of MSx. It seems the decreased concentrations of IGFs edmay be regarded as a potential biomarker for early diagnosis or even prognosis of MSx but need more systematic studies to confirmed it. |
topic |
Metabolic syndrome X Insulin-like growth factor Insulin-like growth factor receptor |
url |
http://link.springer.com/article/10.1186/s13104-019-4492-9 |
work_keys_str_mv |
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