Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

• Main Authors: Ana C. Gonçalves, Ana R. Nunes, Amílcar Falcão, Gilberto Alves, Luís R. Silva
• Format: Article
• Language: English
• Published: MDPI AG 2021-07-01
• Series: Pharmaceuticals
• Subjects: anthocyanins; antioxidants; dietary source; bioavailability; biological activity; biosynthesis
• Online Access: https://www.mdpi.com/1424-8247/14/7/690

In recent years, the consumption of natural-based foods, including beans, fruits, legumes, nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is essentially due to their content in bioactive phytochemicals, with the phenolic compounds standing out. Among them, anthocyanins have been a target of many studies due to the presence of catechol, pyrogallol, and methoxy groups in their chemical structure, which confer notable scavenging, anti-apoptotic, and anti-inflammatory activities, being already recommended as supplementation to mitigate or even attenuate certain disorders, such as diabetes, cancer, and cardiovascular and neurological pathologies. The most well-known anthocyanins are cyanidin 3-<i>O</i>-glucoside and cyanidin 3-<i>O</i>-rutinoside. They are widespread in nature, being present in considerable amounts in red fruits and red vegetables. Overall, the present review intends to discuss the most recent findings on the potential health benefits from the daily intake of anthocyanin-rich foods, as well as their possible pharmacological mechanisms of action. However, before that, some emphasis regarding their chemical structure, dietary sources, and bioavailability was done.