Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
(1) Background: Aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al<sub>2</sub>O<sub>3 </sub>FPs have...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-09-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/19/7114 |
Summary: | (1) Background: Aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al<sub>2</sub>O<sub>3 </sub>FPs have been shown to induce macrophage activation <i>in vitro</i>; however, the inflammatory effect <i>in vivo</i> has not been studied. (2) Methods: We examined the <i>in vivo</i> effect of Al<sub>2</sub>O<sub>3 </sub>FPs on the innate and adaptive immune cells in the mice. (3) Results: Al<sub>2</sub>O<sub>3</sub> FPs promoted the activation of spleen macrophages; however, conventional dendritic cells (cDCs), plasmacytoid DCs (pDCs), and natural killer (NK) cells were not activated. In addition, increases in the CD4 and CD8 T cells was induced in the spleens of the mice treated with Al<sub>2</sub>O<sub>3</sub> FPs, which differentiated into interferon-gamma (IFN-γ)-producing helper T1 (Th1) and cytotoxic T1 (Tc1) cells. Finally, the injection of Al<sub>2</sub>O<sub>3</sub> FPs exacerbated dextran sulfate sodium (DSS)-induced inflammation in the colon, mediated by activated and increased number of CD4 and CD8 T cells. (4) Conclusions: These data demonstrate that FPs of Al<sub>2</sub>O<sub>3 </sub>ceramic may contribute to the exacerbation of inflammatory diseases in the patients. |
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ISSN: | 1661-6596 1422-0067 |