Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells

(1) Background: Aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al<sub>2</sub>O<sub>3 </sub>FPs have...

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Main Authors: Seong-Min Lim, Juyoung Hwang, Hae-Bin Park, Chan Ho Park, Jun-O Jin
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/19/7114
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spelling doaj-1edc438394e3461cb778a144819e5f2a2020-11-25T03:14:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01217114711410.3390/ijms21197114Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T CellsSeong-Min Lim0Juyoung Hwang1Hae-Bin Park2Chan Ho Park3Jun-O Jin4Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, ChinaShanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, ChinaShanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, ChinaDepartment of Orthopedic Surgery, Yeungnam University Medical Center, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, KoreaShanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China(1) Background: Aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al<sub>2</sub>O<sub>3 </sub>FPs have been shown to induce macrophage activation <i>in vitro</i>; however, the inflammatory effect <i>in vivo</i> has not been studied. (2) Methods: We examined the <i>in vivo</i> effect of Al<sub>2</sub>O<sub>3 </sub>FPs on the innate and adaptive immune cells in the mice. (3) Results: Al<sub>2</sub>O<sub>3</sub> FPs promoted the activation of spleen macrophages; however, conventional dendritic cells (cDCs), plasmacytoid DCs (pDCs), and natural killer (NK) cells were not activated. In addition, increases in the CD4 and CD8 T cells was induced in the spleens of the mice treated with Al<sub>2</sub>O<sub>3</sub> FPs, which differentiated into interferon-gamma (IFN-γ)-producing helper T1 (Th1) and cytotoxic T1 (Tc1) cells. Finally, the injection of Al<sub>2</sub>O<sub>3</sub> FPs exacerbated dextran sulfate sodium (DSS)-induced inflammation in the colon, mediated by activated and increased number of CD4 and CD8 T cells. (4) Conclusions: These data demonstrate that FPs of Al<sub>2</sub>O<sub>3 </sub>ceramic may contribute to the exacerbation of inflammatory diseases in the patients.https://www.mdpi.com/1422-0067/21/19/7114Al2O3 FPmacrophageCD4 T cellCD8 T cellinflammation
collection DOAJ
language English
format Article
sources DOAJ
author Seong-Min Lim
Juyoung Hwang
Hae-Bin Park
Chan Ho Park
Jun-O Jin
spellingShingle Seong-Min Lim
Juyoung Hwang
Hae-Bin Park
Chan Ho Park
Jun-O Jin
Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
International Journal of Molecular Sciences
Al2O3 FP
macrophage
CD4 T cell
CD8 T cell
inflammation
author_facet Seong-Min Lim
Juyoung Hwang
Hae-Bin Park
Chan Ho Park
Jun-O Jin
author_sort Seong-Min Lim
title Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
title_short Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
title_full Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
title_fullStr Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
title_full_unstemmed Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
title_sort alumina ceramic exacerbates the inflammatory disease by activation of macrophages and t cells
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-09-01
description (1) Background: Aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al<sub>2</sub>O<sub>3 </sub>FPs have been shown to induce macrophage activation <i>in vitro</i>; however, the inflammatory effect <i>in vivo</i> has not been studied. (2) Methods: We examined the <i>in vivo</i> effect of Al<sub>2</sub>O<sub>3 </sub>FPs on the innate and adaptive immune cells in the mice. (3) Results: Al<sub>2</sub>O<sub>3</sub> FPs promoted the activation of spleen macrophages; however, conventional dendritic cells (cDCs), plasmacytoid DCs (pDCs), and natural killer (NK) cells were not activated. In addition, increases in the CD4 and CD8 T cells was induced in the spleens of the mice treated with Al<sub>2</sub>O<sub>3</sub> FPs, which differentiated into interferon-gamma (IFN-γ)-producing helper T1 (Th1) and cytotoxic T1 (Tc1) cells. Finally, the injection of Al<sub>2</sub>O<sub>3</sub> FPs exacerbated dextran sulfate sodium (DSS)-induced inflammation in the colon, mediated by activated and increased number of CD4 and CD8 T cells. (4) Conclusions: These data demonstrate that FPs of Al<sub>2</sub>O<sub>3 </sub>ceramic may contribute to the exacerbation of inflammatory diseases in the patients.
topic Al2O3 FP
macrophage
CD4 T cell
CD8 T cell
inflammation
url https://www.mdpi.com/1422-0067/21/19/7114
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