Genomic RNA folding mediates assembly of human parechovirus

Genomic RNA folding mediates assembly of human parechovirus

The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.

Bibliographic Details
Main Authors: Shabih Shakeel, Eric C. Dykeman, Simon J. White, Ari Ora, Joseph J.B. Cockburn, Sarah J. Butcher, Peter G. Stockley, Reidun Twarock
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-016-0011-z
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spelling doaj-1edc545ea86c44ca9bf0cec5084edbad2021-01-31T12:32:36ZengNature Publishing GroupNature Communications2041-17232017-02-018111110.1038/s41467-016-0011-zGenomic RNA folding mediates assembly of human parechovirusShabih Shakeel0Eric C. Dykeman1Simon J. White2Ari Ora3Joseph J.B. Cockburn4Sarah J. Butcher5Peter G. Stockley6Reidun Twarock7Institute of Biotechnology and Department of Biosciences, University of HelsinkiDepartments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of YorkAstbury Centre for Structural Molecular Biology, University of LeedsInstitute of Biotechnology and Department of Biosciences, University of HelsinkiAstbury Centre for Structural Molecular Biology, University of LeedsInstitute of Biotechnology and Department of Biosciences, University of HelsinkiAstbury Centre for Structural Molecular Biology, University of LeedsDepartments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of YorkThe mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.https://doi.org/10.1038/s41467-016-0011-z
collection DOAJ
language English
format Article
sources DOAJ
author Shabih Shakeel
Eric C. Dykeman
Simon J. White
Ari Ora
Joseph J.B. Cockburn
Sarah J. Butcher
Peter G. Stockley
Reidun Twarock
spellingShingle Shabih Shakeel
Eric C. Dykeman
Simon J. White
Ari Ora
Joseph J.B. Cockburn
Sarah J. Butcher
Peter G. Stockley
Reidun Twarock
Genomic RNA folding mediates assembly of human parechovirus
Nature Communications
author_facet Shabih Shakeel
Eric C. Dykeman
Simon J. White
Ari Ora
Joseph J.B. Cockburn
Sarah J. Butcher
Peter G. Stockley
Reidun Twarock
author_sort Shabih Shakeel
title Genomic RNA folding mediates assembly of human parechovirus
title_short Genomic RNA folding mediates assembly of human parechovirus
title_full Genomic RNA folding mediates assembly of human parechovirus
title_fullStr Genomic RNA folding mediates assembly of human parechovirus
title_full_unstemmed Genomic RNA folding mediates assembly of human parechovirus
title_sort genomic rna folding mediates assembly of human parechovirus
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-02-01
description The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.
url https://doi.org/10.1038/s41467-016-0011-z
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