Genomic RNA folding mediates assembly of human parechovirus
The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.
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2017-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-016-0011-z |
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doaj-1edc545ea86c44ca9bf0cec5084edbad2021-01-31T12:32:36ZengNature Publishing GroupNature Communications2041-17232017-02-018111110.1038/s41467-016-0011-zGenomic RNA folding mediates assembly of human parechovirusShabih Shakeel0Eric C. Dykeman1Simon J. White2Ari Ora3Joseph J.B. Cockburn4Sarah J. Butcher5Peter G. Stockley6Reidun Twarock7Institute of Biotechnology and Department of Biosciences, University of HelsinkiDepartments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of YorkAstbury Centre for Structural Molecular Biology, University of LeedsInstitute of Biotechnology and Department of Biosciences, University of HelsinkiAstbury Centre for Structural Molecular Biology, University of LeedsInstitute of Biotechnology and Department of Biosciences, University of HelsinkiAstbury Centre for Structural Molecular Biology, University of LeedsDepartments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of YorkThe mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.https://doi.org/10.1038/s41467-016-0011-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock |
spellingShingle |
Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock Genomic RNA folding mediates assembly of human parechovirus Nature Communications |
author_facet |
Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock |
author_sort |
Shabih Shakeel |
title |
Genomic RNA folding mediates assembly of human parechovirus |
title_short |
Genomic RNA folding mediates assembly of human parechovirus |
title_full |
Genomic RNA folding mediates assembly of human parechovirus |
title_fullStr |
Genomic RNA folding mediates assembly of human parechovirus |
title_full_unstemmed |
Genomic RNA folding mediates assembly of human parechovirus |
title_sort |
genomic rna folding mediates assembly of human parechovirus |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-02-01 |
description |
The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly. |
url |
https://doi.org/10.1038/s41467-016-0011-z |
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