Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film
A polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric layers at the interface between the electrolyte and t...
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doaj-1ee35c8b72da424d9c5725329ea880b82020-11-24T22:47:58ZengMDPI AGBiosensors2079-63742018-01-01811210.3390/bios8010012bios8010012Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin FilmAmbran Hartono0Edi Sanjaya1Ramli Ramli2Department of Physics, Faculty of Sciences and Technology, UIN Syarif Hidayatullah Jakarta, Tangerang Selatan, Banten 15412, IndonesiaDepartment of Physics, Faculty of Sciences and Technology, UIN Syarif Hidayatullah Jakarta, Tangerang Selatan, Banten 15412, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang 25131, IndonesiaA polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric layers at the interface between the electrolyte and the electrode. A glucose oxidase (GOx) enzyme was immobilized onto the electrode to oxidize glucose. In practice, the biochemical reaction of glucose with the GOx enzyme generates free electron carriers. Consequently, the potential difference between the electrodes is increased, resulting in a measurable voltage output of the biosensor. The device was tested for various glucose concentrations in the range of 0.013 to 5.85 M, and various GOx enzyme concentrations between 4882.8 and 2.5 million units/L. We found that the sensor output increased with increasing glucose concentration up to 5.85 M. These results indicate that the PVDF film-based capacitive biosensors can be properly applied to glucose sensing and provide opportunities for the low-cost fabrication of glucose-based biosensors based on PVDF materials.http://www.mdpi.com/2079-6374/8/1/12capacitive biosensorglucose sensingGOx enzymePVDF film |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ambran Hartono Edi Sanjaya Ramli Ramli |
spellingShingle |
Ambran Hartono Edi Sanjaya Ramli Ramli Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film Biosensors capacitive biosensor glucose sensing GOx enzyme PVDF film |
author_facet |
Ambran Hartono Edi Sanjaya Ramli Ramli |
author_sort |
Ambran Hartono |
title |
Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film |
title_short |
Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film |
title_full |
Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film |
title_fullStr |
Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film |
title_full_unstemmed |
Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film |
title_sort |
glucose sensing using capacitive biosensor based on polyvinylidene fluoride thin film |
publisher |
MDPI AG |
series |
Biosensors |
issn |
2079-6374 |
publishDate |
2018-01-01 |
description |
A polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric layers at the interface between the electrolyte and the electrode. A glucose oxidase (GOx) enzyme was immobilized onto the electrode to oxidize glucose. In practice, the biochemical reaction of glucose with the GOx enzyme generates free electron carriers. Consequently, the potential difference between the electrodes is increased, resulting in a measurable voltage output of the biosensor. The device was tested for various glucose concentrations in the range of 0.013 to 5.85 M, and various GOx enzyme concentrations between 4882.8 and 2.5 million units/L. We found that the sensor output increased with increasing glucose concentration up to 5.85 M. These results indicate that the PVDF film-based capacitive biosensors can be properly applied to glucose sensing and provide opportunities for the low-cost fabrication of glucose-based biosensors based on PVDF materials. |
topic |
capacitive biosensor glucose sensing GOx enzyme PVDF film |
url |
http://www.mdpi.com/2079-6374/8/1/12 |
work_keys_str_mv |
AT ambranhartono glucosesensingusingcapacitivebiosensorbasedonpolyvinylidenefluoridethinfilm AT edisanjaya glucosesensingusingcapacitivebiosensorbasedonpolyvinylidenefluoridethinfilm AT ramliramli glucosesensingusingcapacitivebiosensorbasedonpolyvinylidenefluoridethinfilm |
_version_ |
1725680311780507648 |