Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion

• Main Authors: Malešić Neda B., Rusmirović Jelena D., Jovašević Jovana S., Perišić Marija D., Dimitrijević Suzana I., Filipović Jovanka M., Tomić Simonida Lj.
• Format: Article
• Language: English
• Published: Savez inženjera i tehničara Srbije 2014-01-01
• Series: Tehnika
• Subjects: 2-Hydroxyethyl methacrylate; Itaconic acid; Hydrogel; Silver(I) ion; Controlled release; Antimicrobial potential
• Online Access: http://scindeks-clanci.ceon.rs/data/pdf/0040-2176/2014/0040-21761404563M.pdf
• ISSN: 0040-2176; 2560-3086

The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time.