Cellular and Molecular Immune Response to Chikungunya Virus Infection
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the...
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doaj-1ee5cc39110a4b80b584d8cb9d3ea0b12020-11-24T23:58:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-10-01810.3389/fcimb.2018.00345411564Cellular and Molecular Immune Response to Chikungunya Virus InfectionIthallo S. B. Tanabe0Eloiza L. L. Tanabe1Elane C. Santos2Wanessa V. Martins3Isadora M. T. C. Araújo4Maria C. A. Cavalcante5Ana R. V. Lima6Niels O. S. Câmara7Leticia Anderson8Leticia Anderson9Dinar Yunusov10Ênio J. Bassi11IMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilLaboratório de Imunobiologia dos Transplantes, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, BrazilIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilCentro Universitário CESMAC, Maceió, BrazilCold Spring Harbor Laboratory, Genome Research Center, Woodbury, NY, United StatesIMUNOREG–Grupo de Pesquisa em Regulação da Resposta Imune, Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, BrazilChikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an updated summary of the current knowledge about immune response to CHIKV and about soluble immunological markers associated with the morbidity, prognosis and chronicity of this arbovirus disease. In addition, we discuss the progress in the research of new vaccines for preventing CHIKV infection and the use of monoclonal antibodies as a promising therapeutic strategy.https://www.frontiersin.org/article/10.3389/fcimb.2018.00345/fullChikungunya virusimmune responseimmunovirologyinnate immunityadaptative immunityimmunological markers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ithallo S. B. Tanabe Eloiza L. L. Tanabe Elane C. Santos Wanessa V. Martins Isadora M. T. C. Araújo Maria C. A. Cavalcante Ana R. V. Lima Niels O. S. Câmara Leticia Anderson Leticia Anderson Dinar Yunusov Ênio J. Bassi |
spellingShingle |
Ithallo S. B. Tanabe Eloiza L. L. Tanabe Elane C. Santos Wanessa V. Martins Isadora M. T. C. Araújo Maria C. A. Cavalcante Ana R. V. Lima Niels O. S. Câmara Leticia Anderson Leticia Anderson Dinar Yunusov Ênio J. Bassi Cellular and Molecular Immune Response to Chikungunya Virus Infection Frontiers in Cellular and Infection Microbiology Chikungunya virus immune response immunovirology innate immunity adaptative immunity immunological markers |
author_facet |
Ithallo S. B. Tanabe Eloiza L. L. Tanabe Elane C. Santos Wanessa V. Martins Isadora M. T. C. Araújo Maria C. A. Cavalcante Ana R. V. Lima Niels O. S. Câmara Leticia Anderson Leticia Anderson Dinar Yunusov Ênio J. Bassi |
author_sort |
Ithallo S. B. Tanabe |
title |
Cellular and Molecular Immune Response to Chikungunya Virus Infection |
title_short |
Cellular and Molecular Immune Response to Chikungunya Virus Infection |
title_full |
Cellular and Molecular Immune Response to Chikungunya Virus Infection |
title_fullStr |
Cellular and Molecular Immune Response to Chikungunya Virus Infection |
title_full_unstemmed |
Cellular and Molecular Immune Response to Chikungunya Virus Infection |
title_sort |
cellular and molecular immune response to chikungunya virus infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2018-10-01 |
description |
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an updated summary of the current knowledge about immune response to CHIKV and about soluble immunological markers associated with the morbidity, prognosis and chronicity of this arbovirus disease. In addition, we discuss the progress in the research of new vaccines for preventing CHIKV infection and the use of monoclonal antibodies as a promising therapeutic strategy. |
topic |
Chikungunya virus immune response immunovirology innate immunity adaptative immunity immunological markers |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2018.00345/full |
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