The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
Abstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participa...
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doaj-1ee8bd45884b4beb8166c621da630c6e2021-08-15T11:28:02ZengNature Publishing GroupScientific Reports2045-23222021-08-0111111410.1038/s41598-021-96035-xThe determinants of lipid profiles in early adolescence in a Ugandan birth cohortJan Pieter R. Koopman0Swaib A. Lule1Christopher Zziwa2Hellen Akurut3Lawrence Lubyayi4Margaret Nampijja5Florence Akello6Priscilla Balungi7Josephine Tumusiime8Gloria Oduru9Alison M. Elliott10Emily L. Webb11John Bradley12Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical MedicineInstitute for Global Health, University College LondonImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research UnitDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical MedicineDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical MedicineAbstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participants in the Entebbe Mother and Baby Study, we used linear regression to examine whether prenatal, childhood or adolescent factors are associated with lipid levels. Reduced high-density lipoprotein (HDL) and elevated triglyceride levels were common (prevalence 31% and 14%, respectively), but elevated low-density lipoprotein (LDL) or total cholesterol (TC) were rare. Current malaria infection was associated with lower mean LDL (adjusted ß − 0.51; 95% CI − 0.81, − 0.21), HDL (adjusted ß − 0.40; 95% CI − 0.56, − 0.23), and TC levels (adjusted ß − 0.62; 95% CI − 0.97, − 0.27), but higher mean triglyceride levels (geometric mean ratio (GMR) 1.47; 95% CI 1.18–1.84). Early-life asymptomatic malaria was associated with modest reductions in HDL and TC. Body mass index (BMI) was positively associated with LDL, TC, and triglycerides. No associations with helminth infection were found. Our findings suggest that early-life factors have only marginal effects on the lipid profile. Current malaria infection and BMI are strongly associated with lipids and important to consider when trying to improve the lipid profile.https://doi.org/10.1038/s41598-021-96035-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley |
spellingShingle |
Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley The determinants of lipid profiles in early adolescence in a Ugandan birth cohort Scientific Reports |
author_facet |
Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley |
author_sort |
Jan Pieter R. Koopman |
title |
The determinants of lipid profiles in early adolescence in a Ugandan birth cohort |
title_short |
The determinants of lipid profiles in early adolescence in a Ugandan birth cohort |
title_full |
The determinants of lipid profiles in early adolescence in a Ugandan birth cohort |
title_fullStr |
The determinants of lipid profiles in early adolescence in a Ugandan birth cohort |
title_full_unstemmed |
The determinants of lipid profiles in early adolescence in a Ugandan birth cohort |
title_sort |
determinants of lipid profiles in early adolescence in a ugandan birth cohort |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-08-01 |
description |
Abstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participants in the Entebbe Mother and Baby Study, we used linear regression to examine whether prenatal, childhood or adolescent factors are associated with lipid levels. Reduced high-density lipoprotein (HDL) and elevated triglyceride levels were common (prevalence 31% and 14%, respectively), but elevated low-density lipoprotein (LDL) or total cholesterol (TC) were rare. Current malaria infection was associated with lower mean LDL (adjusted ß − 0.51; 95% CI − 0.81, − 0.21), HDL (adjusted ß − 0.40; 95% CI − 0.56, − 0.23), and TC levels (adjusted ß − 0.62; 95% CI − 0.97, − 0.27), but higher mean triglyceride levels (geometric mean ratio (GMR) 1.47; 95% CI 1.18–1.84). Early-life asymptomatic malaria was associated with modest reductions in HDL and TC. Body mass index (BMI) was positively associated with LDL, TC, and triglycerides. No associations with helminth infection were found. Our findings suggest that early-life factors have only marginal effects on the lipid profile. Current malaria infection and BMI are strongly associated with lipids and important to consider when trying to improve the lipid profile. |
url |
https://doi.org/10.1038/s41598-021-96035-x |
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