The PI3K/AKT Pathway Is Activated by HGF in NT2D1 Non-Seminoma Cells and Has a Role in the Modulation of Their Malignant Behavior

The PI3K/AKT Pathway Is Activated by HGF in NT2D1 Non-Seminoma Cells and Has a Role in the Modulation of Their Malignant Behavior

Overactivation of the c-MET/HGF system is a feature of many cancers. We previously reported that type II testicular germ cell tumor (TGCT) cells express the c-MET receptor, forming non-seminomatous lesions that are more positive compared with seminomatous ones. Notably, we also demonstrated that NT2...

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Bibliographic Details
Main Authors: Luisa Gesualdi, Erica Leonetti, Alessandra Cucina, Bianca Maria Scicchitano, Silvia Sorrentino, Maria Grazia Tarsitano, Andrea Isidori, Mariano Bizzarri, Antonio Filippini, Anna Riccioli, Marcella Cammarota, Vincenzo Gigantino, Giulia Ricci, Angela Catizone
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
TGCTs
c-MET
HGF
PI3K
PI3K inhibitors
cancer therapy
Online Access:https://www.mdpi.com/1422-0067/21/22/8669

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