Structural basis for dolichylphosphate mannose biosynthesis

The generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis. Here the authors report the structure of dolichylphosphate mannose synthase in complex with bound nucleotide and donor to provide insight into the mechanism of Do...

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Main Authors:	Rosaria Gandini, Tom Reichenbach, Tien-Chye Tan, Christina Divne
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00187-2

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spelling	doaj-1f0af37e72ad462abf59ddbe85ae391e2021-01-31T12:45:51ZengNature Publishing GroupNature Communications2041-17232017-07-018111210.1038/s41467-017-00187-2Structural basis for dolichylphosphate mannose biosynthesisRosaria Gandini0Tom Reichenbach1Tien-Chye Tan2Christina Divne3School of Biotechnology, KTH Royal Institute of TechnologySchool of Biotechnology, KTH Royal Institute of TechnologySchool of Biotechnology, KTH Royal Institute of TechnologySchool of Biotechnology, KTH Royal Institute of TechnologyThe generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis. Here the authors report the structure of dolichylphosphate mannose synthase in complex with bound nucleotide and donor to provide insight into the mechanism of Dol-P-Man synthesis.https://doi.org/10.1038/s41467-017-00187-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rosaria Gandini Tom Reichenbach Tien-Chye Tan Christina Divne
spellingShingle	Rosaria Gandini Tom Reichenbach Tien-Chye Tan Christina Divne Structural basis for dolichylphosphate mannose biosynthesis Nature Communications
author_facet	Rosaria Gandini Tom Reichenbach Tien-Chye Tan Christina Divne
author_sort	Rosaria Gandini
title	Structural basis for dolichylphosphate mannose biosynthesis
title_short	Structural basis for dolichylphosphate mannose biosynthesis
title_full	Structural basis for dolichylphosphate mannose biosynthesis
title_fullStr	Structural basis for dolichylphosphate mannose biosynthesis
title_full_unstemmed	Structural basis for dolichylphosphate mannose biosynthesis
title_sort	structural basis for dolichylphosphate mannose biosynthesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	The generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis. Here the authors report the structure of dolichylphosphate mannose synthase in complex with bound nucleotide and donor to provide insight into the mechanism of Dol-P-Man synthesis.
url	https://doi.org/10.1038/s41467-017-00187-2
work_keys_str_mv	AT rosariagandini structuralbasisfordolichylphosphatemannosebiosynthesis AT tomreichenbach structuralbasisfordolichylphosphatemannosebiosynthesis AT tienchyetan structuralbasisfordolichylphosphatemannosebiosynthesis AT christinadivne structuralbasisfordolichylphosphatemannosebiosynthesis
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Structural basis for dolichylphosphate mannose biosynthesis

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