Photocurable Polymeric Blends for Surgical Application

The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by <sup&g...

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Main Authors:	Teresa Cernadas, Marta Santos, Sónia P. Miguel, Ilídio J. Correia, Patrícia Alves, Paula Ferreira
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Materials
Subjects:	photocuring polymeric blends bioadhesive biocompatibility antibacterial activity
Online Access:	https://www.mdpi.com/1996-1944/13/24/5681

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record_format	Article
spelling	doaj-1f0c76a308e045c6804bff99208a481c2020-12-13T00:01:57ZengMDPI AGMaterials1996-19442020-12-01135681568110.3390/ma13245681Photocurable Polymeric Blends for Surgical ApplicationTeresa Cernadas0Marta Santos1Sónia P. Miguel2Ilídio J. Correia3Patrícia Alves4Paula Ferreira5CIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, PortugalCIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, PortugalCICS-UBI, Health Sciences Research Center, University of Beira Interior, P-6200 506 Covilhã, PortugalCIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, PortugalCIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, PortugalCIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, PortugalThe preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by <sup>1</sup>H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring <i>Escherichia coli</i> and <i>S. aureus</i> growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.https://www.mdpi.com/1996-1944/13/24/5681photocuringpolymeric blendsbioadhesivebiocompatibilityantibacterial activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Teresa Cernadas Marta Santos Sónia P. Miguel Ilídio J. Correia Patrícia Alves Paula Ferreira
spellingShingle	Teresa Cernadas Marta Santos Sónia P. Miguel Ilídio J. Correia Patrícia Alves Paula Ferreira Photocurable Polymeric Blends for Surgical Application Materials photocuring polymeric blends bioadhesive biocompatibility antibacterial activity
author_facet	Teresa Cernadas Marta Santos Sónia P. Miguel Ilídio J. Correia Patrícia Alves Paula Ferreira
author_sort	Teresa Cernadas
title	Photocurable Polymeric Blends for Surgical Application
title_short	Photocurable Polymeric Blends for Surgical Application
title_full	Photocurable Polymeric Blends for Surgical Application
title_fullStr	Photocurable Polymeric Blends for Surgical Application
title_full_unstemmed	Photocurable Polymeric Blends for Surgical Application
title_sort	photocurable polymeric blends for surgical application
publisher	MDPI AG
series	Materials
issn	1996-1944
publishDate	2020-12-01
description	The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by <sup>1</sup>H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring <i>Escherichia coli</i> and <i>S. aureus</i> growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.
topic	photocuring polymeric blends bioadhesive biocompatibility antibacterial activity
url	https://www.mdpi.com/1996-1944/13/24/5681
work_keys_str_mv	AT teresacernadas photocurablepolymericblendsforsurgicalapplication AT martasantos photocurablepolymericblendsforsurgicalapplication AT soniapmiguel photocurablepolymericblendsforsurgicalapplication AT ilidiojcorreia photocurablepolymericblendsforsurgicalapplication AT patriciaalves photocurablepolymericblendsforsurgicalapplication AT paulaferreira photocurablepolymericblendsforsurgicalapplication
_version_	1724385618720456704

Photocurable Polymeric Blends for Surgical Application

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