Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorp...
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2019-09-01
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doaj-1f116d93607149efafc76af989a047e62020-11-25T01:24:53ZengElsevierMaterials Today Bio2590-00642019-09-014Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cellsH. Li0X. Li1Y. Wang2J. Ji3MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaCorresponding author.; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaTo overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorporating active targeting ligand lactobionic acid with pH-sensitive mixed-charge surface. The resulted mixed-charge gold nanoparticles (LA@MC-GNPs) showed resistance to non-specific adsorption of proteins and uptake by HepG2 cells at normal tissue pH 7.4, while they underwent pH-sensitive aggregation and recovered active targeting capability at tumor acidic pH 6.5. The ternary surface modification method provided a simplest strategy to solve the dilemma between passive and active targeting of nanomedicine. Keywords: Mixed-charge, Antifouling, Active targeting, pH sensitivityhttp://www.sciencedirect.com/science/article/pii/S2590006419300602 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
H. Li X. Li Y. Wang J. Ji |
spellingShingle |
H. Li X. Li Y. Wang J. Ji Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells Materials Today Bio |
author_facet |
H. Li X. Li Y. Wang J. Ji |
author_sort |
H. Li |
title |
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
title_short |
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
title_full |
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
title_fullStr |
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
title_full_unstemmed |
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
title_sort |
introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells |
publisher |
Elsevier |
series |
Materials Today Bio |
issn |
2590-0064 |
publishDate |
2019-09-01 |
description |
To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorporating active targeting ligand lactobionic acid with pH-sensitive mixed-charge surface. The resulted mixed-charge gold nanoparticles (LA@MC-GNPs) showed resistance to non-specific adsorption of proteins and uptake by HepG2 cells at normal tissue pH 7.4, while they underwent pH-sensitive aggregation and recovered active targeting capability at tumor acidic pH 6.5. The ternary surface modification method provided a simplest strategy to solve the dilemma between passive and active targeting of nanomedicine. Keywords: Mixed-charge, Antifouling, Active targeting, pH sensitivity |
url |
http://www.sciencedirect.com/science/article/pii/S2590006419300602 |
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