Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells

Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells

To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorp...

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Main Authors: H. Li, X. Li, Y. Wang, J. Ji
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Materials Today Bio
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006419300602
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spelling doaj-1f116d93607149efafc76af989a047e62020-11-25T01:24:53ZengElsevierMaterials Today Bio2590-00642019-09-014Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cellsH. Li0X. Li1Y. Wang2J. Ji3MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaCorresponding author.; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaTo overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorporating active targeting ligand lactobionic acid with pH-sensitive mixed-charge surface. The resulted mixed-charge gold nanoparticles (LA@MC-GNPs) showed resistance to non-specific adsorption of proteins and uptake by HepG2 cells at normal tissue pH 7.4, while they underwent pH-sensitive aggregation and recovered active targeting capability at tumor acidic pH 6.5. The ternary surface modification method provided a simplest strategy to solve the dilemma between passive and active targeting of nanomedicine. Keywords: Mixed-charge, Antifouling, Active targeting, pH sensitivityhttp://www.sciencedirect.com/science/article/pii/S2590006419300602
collection DOAJ
language English
format Article
sources DOAJ
author H. Li
X. Li
Y. Wang
J. Ji
spellingShingle H. Li
X. Li
Y. Wang
J. Ji
Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
Materials Today Bio
author_facet H. Li
X. Li
Y. Wang
J. Ji
author_sort H. Li
title Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
title_short Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
title_full Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
title_fullStr Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
title_full_unstemmed Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
title_sort introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells
publisher Elsevier
series Materials Today Bio
issn 2590-0064
publishDate 2019-09-01
description To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorporating active targeting ligand lactobionic acid with pH-sensitive mixed-charge surface. The resulted mixed-charge gold nanoparticles (LA@MC-GNPs) showed resistance to non-specific adsorption of proteins and uptake by HepG2 cells at normal tissue pH 7.4, while they underwent pH-sensitive aggregation and recovered active targeting capability at tumor acidic pH 6.5. The ternary surface modification method provided a simplest strategy to solve the dilemma between passive and active targeting of nanomedicine. Keywords: Mixed-charge, Antifouling, Active targeting, pH sensitivity
url http://www.sciencedirect.com/science/article/pii/S2590006419300602
work_keys_str_mv AT hli introductionoflactobionicacidligandintomixedchargenanoparticlestorealizeinsitutriggeredactivetargetingtohepatomacells
AT xli introductionoflactobionicacidligandintomixedchargenanoparticlestorealizeinsitutriggeredactivetargetingtohepatomacells
AT ywang introductionoflactobionicacidligandintomixedchargenanoparticlestorealizeinsitutriggeredactivetargetingtohepatomacells
AT jji introductionoflactobionicacidligandintomixedchargenanoparticlestorealizeinsitutriggeredactivetargetingtohepatomacells
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