Exosomes and Exosomal miRNA in Respiratory Diseases
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their conten...
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2016-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2016/5628404 |
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doaj-1f190e011e6d4c40bb2713e8a7a4ec5a2020-11-24T20:53:19ZengHindawi LimitedMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/56284045628404Exosomes and Exosomal miRNA in Respiratory DiseasesShamila D. Alipoor0Esmaeil Mortaz1Johan Garssen2Masoud Movassaghi3Mehdi Mirsaeidi4Ian M. Adcock5Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, NetherlandsDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USADivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USAAirways Disease Section, National Heart & Lung Institute, Imperial College London, London, UKExosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly miRNAs, to both neighboring and distal cells, they are considered important in cell-cell communication. Recent evidence has shown their possible importance in the pathogenesis of several pulmonary diseases. The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. In this review, we summarize recent advances in this area as applicable to pulmonary diseases.http://dx.doi.org/10.1155/2016/5628404 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shamila D. Alipoor Esmaeil Mortaz Johan Garssen Masoud Movassaghi Mehdi Mirsaeidi Ian M. Adcock |
spellingShingle |
Shamila D. Alipoor Esmaeil Mortaz Johan Garssen Masoud Movassaghi Mehdi Mirsaeidi Ian M. Adcock Exosomes and Exosomal miRNA in Respiratory Diseases Mediators of Inflammation |
author_facet |
Shamila D. Alipoor Esmaeil Mortaz Johan Garssen Masoud Movassaghi Mehdi Mirsaeidi Ian M. Adcock |
author_sort |
Shamila D. Alipoor |
title |
Exosomes and Exosomal miRNA in Respiratory Diseases |
title_short |
Exosomes and Exosomal miRNA in Respiratory Diseases |
title_full |
Exosomes and Exosomal miRNA in Respiratory Diseases |
title_fullStr |
Exosomes and Exosomal miRNA in Respiratory Diseases |
title_full_unstemmed |
Exosomes and Exosomal miRNA in Respiratory Diseases |
title_sort |
exosomes and exosomal mirna in respiratory diseases |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2016-01-01 |
description |
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly miRNAs, to both neighboring and distal cells, they are considered important in cell-cell communication. Recent evidence has shown their possible importance in the pathogenesis of several pulmonary diseases. The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. In this review, we summarize recent advances in this area as applicable to pulmonary diseases. |
url |
http://dx.doi.org/10.1155/2016/5628404 |
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1716797475696672768 |