Protein Profiling of Bladder Urothelial Cell Carcinoma.
This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and h...
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doaj-1f24cb47bc664866a0760c4f4b0043da2020-11-24T22:04:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016192210.1371/journal.pone.0161922Protein Profiling of Bladder Urothelial Cell Carcinoma.Jinghai HuFei YeMiao CuiPeng LeeChengguo WeiYuanyuan HaoXiaoqing WangYanbo WangZhihua LuMatthew GalskyRussell McBrideLi WangDongwen WangCarlos Cordon-CardoChunxi WangDavid Y ZhangThis study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.http://europepmc.org/articles/PMC5023150?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinghai Hu Fei Ye Miao Cui Peng Lee Chengguo Wei Yuanyuan Hao Xiaoqing Wang Yanbo Wang Zhihua Lu Matthew Galsky Russell McBride Li Wang Dongwen Wang Carlos Cordon-Cardo Chunxi Wang David Y Zhang |
spellingShingle |
Jinghai Hu Fei Ye Miao Cui Peng Lee Chengguo Wei Yuanyuan Hao Xiaoqing Wang Yanbo Wang Zhihua Lu Matthew Galsky Russell McBride Li Wang Dongwen Wang Carlos Cordon-Cardo Chunxi Wang David Y Zhang Protein Profiling of Bladder Urothelial Cell Carcinoma. PLoS ONE |
author_facet |
Jinghai Hu Fei Ye Miao Cui Peng Lee Chengguo Wei Yuanyuan Hao Xiaoqing Wang Yanbo Wang Zhihua Lu Matthew Galsky Russell McBride Li Wang Dongwen Wang Carlos Cordon-Cardo Chunxi Wang David Y Zhang |
author_sort |
Jinghai Hu |
title |
Protein Profiling of Bladder Urothelial Cell Carcinoma. |
title_short |
Protein Profiling of Bladder Urothelial Cell Carcinoma. |
title_full |
Protein Profiling of Bladder Urothelial Cell Carcinoma. |
title_fullStr |
Protein Profiling of Bladder Urothelial Cell Carcinoma. |
title_full_unstemmed |
Protein Profiling of Bladder Urothelial Cell Carcinoma. |
title_sort |
protein profiling of bladder urothelial cell carcinoma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival. |
url |
http://europepmc.org/articles/PMC5023150?pdf=render |
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