Protein Profiling of Bladder Urothelial Cell Carcinoma.

• Main Authors: Jinghai Hu, Fei Ye, Miao Cui, Peng Lee, Chengguo Wei, Yuanyuan Hao, Xiaoqing Wang, Yanbo Wang, Zhihua Lu, Matthew Galsky, Russell McBride, Li Wang, Dongwen Wang, Carlos Cordon-Cardo, Chunxi Wang, David Y Zhang
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2016-01-01
• Series: PLoS ONE
• Online Access: http://europepmc.org/articles/PMC5023150?pdf=render

This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.