Allogeneic mesenchymal stem cells for treatment of severe burn injury

• Main Authors: Marc G. Jeschke, Sarah Rehou, Matthew R. McCann, Shahriar Shahrokhi
• Format: Article
• Language: English
• Published: BMC 2019-11-01
• Series: Stem Cell Research & Therapy
• Subjects: Burns; Cell therapy; Mesenchymal stem cells; Wound healing
• Online Access: http://link.springer.com/article/10.1186/s13287-019-1465-9

Abstract The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.