ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis

ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis

Abstract Background Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast cancer molecular subtypes, including oestrogen receptor-positive disease, with life expectancy of less than a year. While e...

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Bibliographic Details
Main Authors: Sara Charmsaz, Ben Doherty, Sinéad Cocchiglia, Damir Varešlija, Attilio Marino, Nicola Cosgrove, Ricardo Marques, Nolan Priedigkeit, Siobhan Purcell, Fiona Bane, Jarlath Bolger, Christopher Byrne, Philip J. O’Halloran, Francesca Brett, Katherine Sheehan, Kieran Brennan, Ann M. Hopkins, Stephen Keelan, Petra Jagust, Stephen Madden, Chiara Martinelli, Matteo Battaglini, Steffi Oesterreich, Adrian V. Lee, Gianni Ciofani, Arnold D. K. Hill, Leonie S. Young
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Medicine
Subjects:
Breast cancer metastases
Brain metastases
ADAM22
LGI1
ECM signalling
Blood–brain barrier
Online Access:http://link.springer.com/article/10.1186/s12916-020-01806-4

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