Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada
Abstract Objective The epidemiology of chronic myeloid leukemia is shifting due to the aging global population and the recent discovery and availability of targeted treatment options. This study provides recent data regarding the incidence of CML in Calgary, a major Canadian city. Data from patients...
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doaj-1f417789f4b840d8afb7e8ab5c050dcc2020-11-25T02:06:54ZengBMCBMC Research Notes1756-05002018-11-011111510.1186/s13104-018-3890-8Incidence of chronic myeloid leukemia in Calgary, Alberta, CanadaLeonard Tu Nguyen0Maggie Guo1Christopher Naugler2Fariborz Rashid-Kolvear3Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of CalgaryDepartment of Pathology and Laboratory Medicine, Cumming School of Medicine, University of CalgaryDepartment of Pathology and Laboratory Medicine, Cumming School of Medicine, University of CalgaryDepartment of Pathology and Laboratory Medicine, Cumming School of Medicine, University of CalgaryAbstract Objective The epidemiology of chronic myeloid leukemia is shifting due to the aging global population and the recent discovery and availability of targeted treatment options. This study provides recent data regarding the incidence of CML in Calgary, a major Canadian city. Data from patients diagnosed with CML by bone marrow sample analysis from 2011 to 2015 were collected from the database of the sole centralized cytogenetics facility in service of Calgary and its surrounding area. Results With an average of 10.2 newly diagnosed cases per year in Calgary from 2011 to 2015, the incidence rate was calculated to be 0.75 cases per 100,000 person-years (95% CI 0.57–0.99). With age standardization, the incidence was 0.87 cases per 100,000 person-years (95% CI 0.82–0.91) for the Canadian population, which was low compared to other developed Western nations. The highest incidence rates were observed in the older patient categories, however there was a broad age distribution for incident cases and the median age at diagnosis was 48. There was a general male bias for CML most pronounced at the younger ages. Our description of CML incidence will help to inform healthcare planners amidst the dramatically altered treatment of this hematological neoplasm.http://link.springer.com/article/10.1186/s13104-018-3890-8Chronic myeloid leukemiaChronic myelogenous leukemiaMyeloproliferative neoplasmCancer epidemiologyHematological neoplasm, incidenceCanada |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leonard Tu Nguyen Maggie Guo Christopher Naugler Fariborz Rashid-Kolvear |
spellingShingle |
Leonard Tu Nguyen Maggie Guo Christopher Naugler Fariborz Rashid-Kolvear Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada BMC Research Notes Chronic myeloid leukemia Chronic myelogenous leukemia Myeloproliferative neoplasm Cancer epidemiology Hematological neoplasm, incidence Canada |
author_facet |
Leonard Tu Nguyen Maggie Guo Christopher Naugler Fariborz Rashid-Kolvear |
author_sort |
Leonard Tu Nguyen |
title |
Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada |
title_short |
Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada |
title_full |
Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada |
title_fullStr |
Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada |
title_full_unstemmed |
Incidence of chronic myeloid leukemia in Calgary, Alberta, Canada |
title_sort |
incidence of chronic myeloid leukemia in calgary, alberta, canada |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2018-11-01 |
description |
Abstract Objective The epidemiology of chronic myeloid leukemia is shifting due to the aging global population and the recent discovery and availability of targeted treatment options. This study provides recent data regarding the incidence of CML in Calgary, a major Canadian city. Data from patients diagnosed with CML by bone marrow sample analysis from 2011 to 2015 were collected from the database of the sole centralized cytogenetics facility in service of Calgary and its surrounding area. Results With an average of 10.2 newly diagnosed cases per year in Calgary from 2011 to 2015, the incidence rate was calculated to be 0.75 cases per 100,000 person-years (95% CI 0.57–0.99). With age standardization, the incidence was 0.87 cases per 100,000 person-years (95% CI 0.82–0.91) for the Canadian population, which was low compared to other developed Western nations. The highest incidence rates were observed in the older patient categories, however there was a broad age distribution for incident cases and the median age at diagnosis was 48. There was a general male bias for CML most pronounced at the younger ages. Our description of CML incidence will help to inform healthcare planners amidst the dramatically altered treatment of this hematological neoplasm. |
topic |
Chronic myeloid leukemia Chronic myelogenous leukemia Myeloproliferative neoplasm Cancer epidemiology Hematological neoplasm, incidence Canada |
url |
http://link.springer.com/article/10.1186/s13104-018-3890-8 |
work_keys_str_mv |
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