Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties in cultured rat hippocampal neurons (Perissin...

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Bibliographic Details
Main Authors: Paula Patricia Perissinotti, Elizabeth G. Ethington, Erik eAlmazan, Elizabeth eMartínez-Hernández, Jennifer eKalil, Michael D. Koob, Erika S. Piedras-Renteria
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
actin-binding proteins
HVA
SCA8
Synapsin I
Kelch-like 1 protein
T-type voltage-gated calcium channels
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00444/full

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