Network structure of brain atrophy in de novo Parkinson's disease
We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified...
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doaj-1f573f7add014282a4e4afd5b955ab8b2021-05-05T00:00:24ZengeLife Sciences Publications LtdeLife2050-084X2015-09-01410.7554/eLife.08440Network structure of brain atrophy in de novo Parkinson's diseaseYashar Zeighami0Miguel Ulla1Yasser Iturria-Medina2Mahsa Dadar3Yu Zhang4Kevin Michel-Herve Larcher5Vladimir Fonov6Alan C Evans7D Louis Collins8Alain Dagher9https://orcid.org/0000-0002-0945-5779McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada; Service de Neurologie A, CHU Clermont-Ferrand, Clermont-Ferrand, FranceMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, CanadaWe mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation.https://elifesciences.org/articles/08440MRIsubstantia nigrabasal gangliaindependent component analysisdeformation-based morphometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yashar Zeighami Miguel Ulla Yasser Iturria-Medina Mahsa Dadar Yu Zhang Kevin Michel-Herve Larcher Vladimir Fonov Alan C Evans D Louis Collins Alain Dagher |
spellingShingle |
Yashar Zeighami Miguel Ulla Yasser Iturria-Medina Mahsa Dadar Yu Zhang Kevin Michel-Herve Larcher Vladimir Fonov Alan C Evans D Louis Collins Alain Dagher Network structure of brain atrophy in de novo Parkinson's disease eLife MRI substantia nigra basal ganglia independent component analysis deformation-based morphometry |
author_facet |
Yashar Zeighami Miguel Ulla Yasser Iturria-Medina Mahsa Dadar Yu Zhang Kevin Michel-Herve Larcher Vladimir Fonov Alan C Evans D Louis Collins Alain Dagher |
author_sort |
Yashar Zeighami |
title |
Network structure of brain atrophy in de novo Parkinson's disease |
title_short |
Network structure of brain atrophy in de novo Parkinson's disease |
title_full |
Network structure of brain atrophy in de novo Parkinson's disease |
title_fullStr |
Network structure of brain atrophy in de novo Parkinson's disease |
title_full_unstemmed |
Network structure of brain atrophy in de novo Parkinson's disease |
title_sort |
network structure of brain atrophy in de novo parkinson's disease |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2015-09-01 |
description |
We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation. |
topic |
MRI substantia nigra basal ganglia independent component analysis deformation-based morphometry |
url |
https://elifesciences.org/articles/08440 |
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