Shaping Innate Lymphoid Cell Diversity
Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We...
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doaj-1f5bc8fc41524667ade46c333c8901c92020-11-24T21:24:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01569307548Shaping Innate Lymphoid Cell DiversityQiutong Huang0Qiutong Huang1Cyril Seillet2Cyril Seillet3Gabrielle T. Belz4Gabrielle T. Belz5Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Medical Biology, University of Melbourne, Melbourne, VIC, AustraliaWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Medical Biology, University of Melbourne, Melbourne, VIC, AustraliaWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Medical Biology, University of Melbourne, Melbourne, VIC, AustraliaInnate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01569/fullinnate immunitydifferentiationgene expressionimmune protectioninnate lymphoid cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiutong Huang Qiutong Huang Cyril Seillet Cyril Seillet Gabrielle T. Belz Gabrielle T. Belz |
spellingShingle |
Qiutong Huang Qiutong Huang Cyril Seillet Cyril Seillet Gabrielle T. Belz Gabrielle T. Belz Shaping Innate Lymphoid Cell Diversity Frontiers in Immunology innate immunity differentiation gene expression immune protection innate lymphoid cell |
author_facet |
Qiutong Huang Qiutong Huang Cyril Seillet Cyril Seillet Gabrielle T. Belz Gabrielle T. Belz |
author_sort |
Qiutong Huang |
title |
Shaping Innate Lymphoid Cell Diversity |
title_short |
Shaping Innate Lymphoid Cell Diversity |
title_full |
Shaping Innate Lymphoid Cell Diversity |
title_fullStr |
Shaping Innate Lymphoid Cell Diversity |
title_full_unstemmed |
Shaping Innate Lymphoid Cell Diversity |
title_sort |
shaping innate lymphoid cell diversity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2017-11-01 |
description |
Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces. |
topic |
innate immunity differentiation gene expression immune protection innate lymphoid cell |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01569/full |
work_keys_str_mv |
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1725990068471988224 |