Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syri...

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Main Authors: Brandi N. Williamson, Joseph Prescott, Jose L. Garrido, Raymond A. Alvarez, Heinz Feldmann, Maria I. Barría
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2021-10-01
Series:Emerging Infectious Diseases
Subjects:
recombinant human monoclonal antibodies
Andes orthohantavirus
Syrian hamster
viruses
zoonoses
Online Access:https://wwwnc.cdc.gov/eid/article/27/10/21-0735_article
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spelling doaj-1f5f799122d1481f90e267d97e87fac02021-09-20T16:38:19ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-10-0127102707271010.3201/eid2710.210735Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian HamstersBrandi N. WilliamsonJoseph PrescottJose L. GarridoRaymond A. AlvarezHeinz FeldmannMaria I. Barría Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease. https://wwwnc.cdc.gov/eid/article/27/10/21-0735_articlerecombinant human monoclonal antibodiesAndes orthohantavirusSyrian hamsterviruseszoonoses
collection DOAJ
language English
format Article
sources DOAJ
author Brandi N. Williamson
Joseph Prescott
Jose L. Garrido
Raymond A. Alvarez
Heinz Feldmann
Maria I. Barría
spellingShingle Brandi N. Williamson
Joseph Prescott
Jose L. Garrido
Raymond A. Alvarez
Heinz Feldmann
Maria I. Barría
Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
Emerging Infectious Diseases
recombinant human monoclonal antibodies
Andes orthohantavirus
Syrian hamster
viruses
zoonoses
author_facet Brandi N. Williamson
Joseph Prescott
Jose L. Garrido
Raymond A. Alvarez
Heinz Feldmann
Maria I. Barría
author_sort Brandi N. Williamson
title Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_short Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_full Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_fullStr Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_full_unstemmed Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_sort therapeutic efficacy of human monoclonal antibodies against andes virus infection in syrian hamsters
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2021-10-01
description Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
topic recombinant human monoclonal antibodies
Andes orthohantavirus
Syrian hamster
viruses
zoonoses
url https://wwwnc.cdc.gov/eid/article/27/10/21-0735_article
work_keys_str_mv AT brandinwilliamson therapeuticefficacyofhumanmonoclonalantibodiesagainstandesvirusinfectioninsyrianhamsters
AT josephprescott therapeuticefficacyofhumanmonoclonalantibodiesagainstandesvirusinfectioninsyrianhamsters
AT joselgarrido therapeuticefficacyofhumanmonoclonalantibodiesagainstandesvirusinfectioninsyrianhamsters
AT raymondaalvarez therapeuticefficacyofhumanmonoclonalantibodiesagainstandesvirusinfectioninsyrianhamsters
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