The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD
Purpose: To investigate whether the coronavirus disease 2019 (COVID-19) pandemic-associated postponement in care had effects on the baseline clinical presentation of patients with newly diagnosed treatment-naïve exudative neovascular age-related macular degeneration (AMD). Methods: We included the f...
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doaj-1f61202eabdd42739f8eba1285551b842021-03-19T00:05:13ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01101265126510.3390/jcm10061265The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMDEnrico Borrelli0Marco Battista1Giovanna Vella2Domenico Grosso3Riccardo Sacconi4Lea Querques5Ilaria Zucchiatti6Francesco Prascina7Francesco Bandello8Giuseppe Querques9Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDepartment of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyPurpose: To investigate whether the coronavirus disease 2019 (COVID-19) pandemic-associated postponement in care had effects on the baseline clinical presentation of patients with newly diagnosed treatment-naïve exudative neovascular age-related macular degeneration (AMD). Methods: We included the first 50 consecutive patients referred within the COVID-19 pandemic with a diagnosis of treatment-naïve exudative neovascular AMD. Two groups of fifty consecutive patients with newly diagnosed neovascular exudative AMD presenting in 2018 and 2019 (control periods) were also included for comparisons. Results: Baseline visual acuity was statistically worse in patients referred during the COVID-19 pandemic period (0.87 ± 0.51 logarithm of the minimum angle of resolution (LogMAR)) as compared with both the “2019” (0.67 ± 0.48 LogMAR, <i>p</i> = 0.001) and “2018” (0.69 ± 0.54 LogMAR, <i>p</i> = 0.012) control periods. Data on the visual function after a loading dose of anti-vascular endothelial growth factor (VEGF) was available in a subset of patients (43 subjects in 2020, 45 in 2019 and 46 in 2018, respectively). Mean ± SD best corrected visual acuity (BCVA) at the 1-month follow-up visit after the third anti-VEGF injection was still worse in patients referred during the COVID-19 pandemic (0.82 ± 0.66 LogMAR) as compared with both the “2019” (0.60 ± 0.45 LogMAR, <i>p</i> = 0.021) and “2018” (0.55 ± 0.53 LogMAR, <i>p</i> = 0.001) control periods. On structural optical coherence tomography (OCT), the maximum subretinal hyperreflective material (SHRM) height and width were significantly greater in the COVID-19 pandemic patients. Conclusions: We demonstrated that patients with newly diagnosed treatment-naïve exudative neovascular AMD referred during the COVID-19 pandemic had worse clinical characteristics at presentation and short-term visual outcomes.https://www.mdpi.com/2077-0383/10/6/1265COVID-19retinaneovascular AMDoutcome |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Enrico Borrelli Marco Battista Giovanna Vella Domenico Grosso Riccardo Sacconi Lea Querques Ilaria Zucchiatti Francesco Prascina Francesco Bandello Giuseppe Querques |
spellingShingle |
Enrico Borrelli Marco Battista Giovanna Vella Domenico Grosso Riccardo Sacconi Lea Querques Ilaria Zucchiatti Francesco Prascina Francesco Bandello Giuseppe Querques The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD Journal of Clinical Medicine COVID-19 retina neovascular AMD outcome |
author_facet |
Enrico Borrelli Marco Battista Giovanna Vella Domenico Grosso Riccardo Sacconi Lea Querques Ilaria Zucchiatti Francesco Prascina Francesco Bandello Giuseppe Querques |
author_sort |
Enrico Borrelli |
title |
The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD |
title_short |
The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD |
title_full |
The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD |
title_fullStr |
The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD |
title_full_unstemmed |
The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD |
title_sort |
covid-19 pandemic has had negative effects on baseline clinical presentation and outcomes of patients with newly diagnosed treatment-naïve exudative amd |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-03-01 |
description |
Purpose: To investigate whether the coronavirus disease 2019 (COVID-19) pandemic-associated postponement in care had effects on the baseline clinical presentation of patients with newly diagnosed treatment-naïve exudative neovascular age-related macular degeneration (AMD). Methods: We included the first 50 consecutive patients referred within the COVID-19 pandemic with a diagnosis of treatment-naïve exudative neovascular AMD. Two groups of fifty consecutive patients with newly diagnosed neovascular exudative AMD presenting in 2018 and 2019 (control periods) were also included for comparisons. Results: Baseline visual acuity was statistically worse in patients referred during the COVID-19 pandemic period (0.87 ± 0.51 logarithm of the minimum angle of resolution (LogMAR)) as compared with both the “2019” (0.67 ± 0.48 LogMAR, <i>p</i> = 0.001) and “2018” (0.69 ± 0.54 LogMAR, <i>p</i> = 0.012) control periods. Data on the visual function after a loading dose of anti-vascular endothelial growth factor (VEGF) was available in a subset of patients (43 subjects in 2020, 45 in 2019 and 46 in 2018, respectively). Mean ± SD best corrected visual acuity (BCVA) at the 1-month follow-up visit after the third anti-VEGF injection was still worse in patients referred during the COVID-19 pandemic (0.82 ± 0.66 LogMAR) as compared with both the “2019” (0.60 ± 0.45 LogMAR, <i>p</i> = 0.021) and “2018” (0.55 ± 0.53 LogMAR, <i>p</i> = 0.001) control periods. On structural optical coherence tomography (OCT), the maximum subretinal hyperreflective material (SHRM) height and width were significantly greater in the COVID-19 pandemic patients. Conclusions: We demonstrated that patients with newly diagnosed treatment-naïve exudative neovascular AMD referred during the COVID-19 pandemic had worse clinical characteristics at presentation and short-term visual outcomes. |
topic |
COVID-19 retina neovascular AMD outcome |
url |
https://www.mdpi.com/2077-0383/10/6/1265 |
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