Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol
Background Ageing is associated with an increased prevalence of comorbidities and sarcopenia as well as a decline of functional reserve of multiple organ systems, which may lead, in the context of the disease-related and/or treatment-related stress, to functional deconditioning. The multicomponent ‘...
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BMJ Publishing Group
2021-04-01
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Series: | BMJ Open |
Online Access: | https://bmjopen.bmj.com/content/11/4/e042960.full |
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language |
English |
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sources |
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author |
Benjamin Riche Laetitia Stefani Virginie Pitiot Vincent Collange Mélanie Roche Christine Ravot Amélie Malapert Sophie Paget-Bailly Charlène Garandeau Mélanie Tomatis Béatrice Galamand Marion Granger Claire Barbavara Chrystelle Bourgeois Evelyne Genest Max Haïne Elisabeth Castel-Kremer Isabelle Morel-Soldner Olivia Le Saux David Dayde Claire Falandry G. Albrand D. Barnoud D. Benayoun B Billod J. Bonhomme A.-L. Bres C. Brunengo A. Chanelière Y. Chauleur G. Copaescu H. Curé A-M. Dascalita B. De La Vigerie S. Ducoulombier O. Ganne F. Gervais T. Gilbert M. Giroud R. Guyot M. Haïne N. Jomard C. Lecardonnel B. Leroy J-A. Long A. Marion E. Nony S. Parent A. Pelisset-Vanhersecke A. Pirollet J-E. Terrier J. Trautmann M-A. Vincent |
spellingShingle |
Benjamin Riche Laetitia Stefani Virginie Pitiot Vincent Collange Mélanie Roche Christine Ravot Amélie Malapert Sophie Paget-Bailly Charlène Garandeau Mélanie Tomatis Béatrice Galamand Marion Granger Claire Barbavara Chrystelle Bourgeois Evelyne Genest Max Haïne Elisabeth Castel-Kremer Isabelle Morel-Soldner Olivia Le Saux David Dayde Claire Falandry G. Albrand D. Barnoud D. Benayoun B Billod J. Bonhomme A.-L. Bres C. Brunengo A. Chanelière Y. Chauleur G. Copaescu H. Curé A-M. Dascalita B. De La Vigerie S. Ducoulombier O. Ganne F. Gervais T. Gilbert M. Giroud R. Guyot M. Haïne N. Jomard C. Lecardonnel B. Leroy J-A. Long A. Marion E. Nony S. Parent A. Pelisset-Vanhersecke A. Pirollet J-E. Terrier J. Trautmann M-A. Vincent Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol BMJ Open |
author_facet |
Benjamin Riche Laetitia Stefani Virginie Pitiot Vincent Collange Mélanie Roche Christine Ravot Amélie Malapert Sophie Paget-Bailly Charlène Garandeau Mélanie Tomatis Béatrice Galamand Marion Granger Claire Barbavara Chrystelle Bourgeois Evelyne Genest Max Haïne Elisabeth Castel-Kremer Isabelle Morel-Soldner Olivia Le Saux David Dayde Claire Falandry G. Albrand D. Barnoud D. Benayoun B Billod J. Bonhomme A.-L. Bres C. Brunengo A. Chanelière Y. Chauleur G. Copaescu H. Curé A-M. Dascalita B. De La Vigerie S. Ducoulombier O. Ganne F. Gervais T. Gilbert M. Giroud R. Guyot M. Haïne N. Jomard C. Lecardonnel B. Leroy J-A. Long A. Marion E. Nony S. Parent A. Pelisset-Vanhersecke A. Pirollet J-E. Terrier J. Trautmann M-A. Vincent |
author_sort |
Benjamin Riche |
title |
Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol |
title_short |
Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol |
title_full |
Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol |
title_fullStr |
Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol |
title_full_unstemmed |
Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol |
title_sort |
feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the proadapt pilot study protocol |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-04-01 |
description |
Background Ageing is associated with an increased prevalence of comorbidities and sarcopenia as well as a decline of functional reserve of multiple organ systems, which may lead, in the context of the disease-related and/or treatment-related stress, to functional deconditioning. The multicomponent ‘Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning risk and Accompaniment of Patients’ Trajectories (PROADAPT)’ intervention was developed multiprofessionally to implement prehabilitation in older patients with cancer.Methods The PROADAPT pilot study is an interventional, non-comparative, prospective, multicentre study. It will include 122 patients oriented to complex medical–surgical curative procedures (major surgery or radiation therapy with or without chemotherapy). After informed consent, patients will undergo a comprehensive geriatric assessment and will be offered a prehabilitation kit that includes an advice booklet with personalised objectives and respiratory rehabilitation devices. Patients will then be called weekly and monitored for physical and respiratory rehabilitation, preoperative renutrition, motivational counselling and iatrogenic prevention. Six outpatient visits will be planned: at inclusion, a few days before the procedure and at 1, 3, 6 and 12 months after the end of the procedure. The main outcome of the study is the feasibility of the intervention, defined as the ability to perform at least one of the components of the programme. Clinical data collected will include patient-specific and cancer-specific characteristics.Ethics and dissemination The study protocol was approved by the Ile de France 8 ethics committee on 5 June 2018. The results of the primary and secondary objectives will be published in peer-reviewed journals.Trial registration number NCT03659123. Pre-results of the trial. |
url |
https://bmjopen.bmj.com/content/11/4/e042960.full |
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doaj-1f6601a855504989933c6184bddcd50a2021-07-23T15:00:32ZengBMJ Publishing GroupBMJ Open2044-60552021-04-0111410.1136/bmjopen-2020-042960Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocolBenjamin Riche0Laetitia Stefani1Virginie Pitiot2Vincent Collange3Mélanie Roche4Christine Ravot5Amélie Malapert6Sophie Paget-Bailly7Charlène Garandeau8Mélanie Tomatis9Béatrice Galamand10Marion Granger11Claire Barbavara12Chrystelle Bourgeois13Evelyne Genest14Max Haïne15Elisabeth Castel-Kremer16Isabelle Morel-Soldner17Olivia Le Saux18David Dayde19Claire Falandry20G. AlbrandD. BarnoudD. BenayounB BillodJ. BonhommeA.-L. BresC. BrunengoA. ChanelièreY. ChauleurG. CopaescuH. CuréA-M. DascalitaB. De La VigerieS. DucoulombierO. GanneF. GervaisT. GilbertM. GiroudR. GuyotM. HaïneN. JomardC. LecardonnelB. LeroyJ-A. LongA. MarionE. NonyS. ParentA. Pelisset-VanherseckeA. PirolletJ-E. TerrierJ. TrautmannM-A. VincentService de Biostatistique – Bioinformatique, Pôle Santé Publique, Hospices Civils de Lyon, Lyon, FranceDepartment of Medical Oncology, Centre Hospitalier Annecy Genevois, Pringy, FrancePlateforme Transversale de Recherche de l’IC-HCL, Hospices Civils de Lyon, Lyon, FranceDépartement anesthésie réanimation, Medipole Lyon-Villeurbanne, Villeurbanne, FrancePlateforme Transversale de Recherche de l’IC-HCL, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, FrancePlateforme Transversale de Recherche de l’IC-HCL, Hospices Civils de Lyon, Lyon, FranceMethodology and Quality of Life Unit in Oncology, University Hospital Centre Besancon, Besancon, FranceDirection à la Recherche Clinique et à l'Innovation, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Hospices Civils de Lyon, Lyon, FranceDepartment of Medical Oncology, Centre Hospitalier Annecy Genevois, Pringy, FranceGeriatrics Unit, Hospices Civils de Lyon, Lyon, FrancePôle de gérontologie et Médecine de Réadaptation, Hôpital Nord-Ouest, Villefranche-sur-Saone, FranceGeriatrics Unit, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Centre Hospitalier de la Croix Rousse, Hospices Civils de Lyon, Lyon, FranceTherapeutic targeting of the tumor cell and its immune microenvironment, Centre de Recherche en Cancerologie de Lyon, Lyon, FrancePlateforme Transversale de Recherche de l’IC-HCL, Hospices Civils de Lyon, Lyon, FranceGeriatrics Unit, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, FranceBackground Ageing is associated with an increased prevalence of comorbidities and sarcopenia as well as a decline of functional reserve of multiple organ systems, which may lead, in the context of the disease-related and/or treatment-related stress, to functional deconditioning. The multicomponent ‘Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning risk and Accompaniment of Patients’ Trajectories (PROADAPT)’ intervention was developed multiprofessionally to implement prehabilitation in older patients with cancer.Methods The PROADAPT pilot study is an interventional, non-comparative, prospective, multicentre study. It will include 122 patients oriented to complex medical–surgical curative procedures (major surgery or radiation therapy with or without chemotherapy). After informed consent, patients will undergo a comprehensive geriatric assessment and will be offered a prehabilitation kit that includes an advice booklet with personalised objectives and respiratory rehabilitation devices. Patients will then be called weekly and monitored for physical and respiratory rehabilitation, preoperative renutrition, motivational counselling and iatrogenic prevention. Six outpatient visits will be planned: at inclusion, a few days before the procedure and at 1, 3, 6 and 12 months after the end of the procedure. The main outcome of the study is the feasibility of the intervention, defined as the ability to perform at least one of the components of the programme. Clinical data collected will include patient-specific and cancer-specific characteristics.Ethics and dissemination The study protocol was approved by the Ile de France 8 ethics committee on 5 June 2018. The results of the primary and secondary objectives will be published in peer-reviewed journals.Trial registration number NCT03659123. Pre-results of the trial.https://bmjopen.bmj.com/content/11/4/e042960.full |