Aurora A Protein Kinase: To the Centrosome and Beyond

Aurora A Protein Kinase: To the Centrosome and Beyond

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of A...

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Bibliographic Details
Main Authors: Laura Magnaghi-Jaulin, Grégory Eot-Houllier, Emmanuel Gallaud, Régis Giet
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Biomolecules
Subjects:
Aurora A protein kinase, centrosome, mitotic spindle, polarity, centromere, kinetochore, cohesion, transcription
Online Access:http://www.mdpi.com/2218-273X/9/1/28
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spelling doaj-1f723f1cd70e47a9a3c79205a0370f522020-11-25T00:45:59ZengMDPI AGBiomolecules2218-273X2019-01-01912810.3390/biom9010028biom9010028Aurora A Protein Kinase: To the Centrosome and BeyondLaura Magnaghi-Jaulin0Grégory Eot-Houllier1Emmanuel Gallaud2Régis Giet3University of Rennes, CNRS UMR 6290, IGDR-Institute of Genetics and Development of Rennes, F-35000 Rennes, FranceUniversity of Rennes, CNRS UMR 6290, IGDR-Institute of Genetics and Development of Rennes, F-35000 Rennes, FranceUniversity of Rennes, CNRS UMR 6290, IGDR-Institute of Genetics and Development of Rennes, F-35000 Rennes, FranceUniversity of Rennes, CNRS UMR 6290, IGDR-Institute of Genetics and Development of Rennes, F-35000 Rennes, FranceAccurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division.http://www.mdpi.com/2218-273X/9/1/28Aurora A protein kinase, centrosome, mitotic spindle, polarity, centromere, kinetochore, cohesion, transcription
collection DOAJ
language English
format Article
sources DOAJ
author Laura Magnaghi-Jaulin
Grégory Eot-Houllier
Emmanuel Gallaud
Régis Giet
spellingShingle Laura Magnaghi-Jaulin
Grégory Eot-Houllier
Emmanuel Gallaud
Régis Giet
Aurora A Protein Kinase: To the Centrosome and Beyond
Biomolecules
Aurora A protein kinase, centrosome, mitotic spindle, polarity, centromere, kinetochore, cohesion, transcription
author_facet Laura Magnaghi-Jaulin
Grégory Eot-Houllier
Emmanuel Gallaud
Régis Giet
author_sort Laura Magnaghi-Jaulin
title Aurora A Protein Kinase: To the Centrosome and Beyond
title_short Aurora A Protein Kinase: To the Centrosome and Beyond
title_full Aurora A Protein Kinase: To the Centrosome and Beyond
title_fullStr Aurora A Protein Kinase: To the Centrosome and Beyond
title_full_unstemmed Aurora A Protein Kinase: To the Centrosome and Beyond
title_sort aurora a protein kinase: to the centrosome and beyond
publisher MDPI AG
series Biomolecules
issn 2218-273X
publishDate 2019-01-01
description Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division.
topic Aurora A protein kinase, centrosome, mitotic spindle, polarity, centromere, kinetochore, cohesion, transcription
url http://www.mdpi.com/2218-273X/9/1/28
work_keys_str_mv AT lauramagnaghijaulin auroraaproteinkinasetothecentrosomeandbeyond
AT gregoryeothoullier auroraaproteinkinasetothecentrosomeandbeyond
AT emmanuelgallaud auroraaproteinkinasetothecentrosomeandbeyond
AT regisgiet auroraaproteinkinasetothecentrosomeandbeyond
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