Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight
Spaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculat...
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doaj-1f75f855adda490f863108063c167cf52020-11-24T20:41:33ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-10-011810215310.3390/ijms18102153ijms18102153Redox Signaling and Its Impact on Skeletal and Vascular Responses to SpaceflightCandice G. T. Tahimic0Ruth K. Globus1Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USASpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USASpaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculature at the level of the whole organism. Recent experiments from spaceflight and ground-based models have provided fresh insights into how these environmental stresses influence mechanisms that are related to redox signaling, oxidative stress, and tissue dysfunction. Emerging mechanistic knowledge on cellular defenses to radiation and other environmental stressors, including microgravity, are useful for both screening and developing interventions against spaceflight-induced deficits in bone and vascular function.https://www.mdpi.com/1422-0067/18/10/2153spaceflightbonevasculatureoxidative stressmicrogravityhindlimb unloadingradiationreactive oxygen speciesantioxidant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Candice G. T. Tahimic Ruth K. Globus |
spellingShingle |
Candice G. T. Tahimic Ruth K. Globus Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight International Journal of Molecular Sciences spaceflight bone vasculature oxidative stress microgravity hindlimb unloading radiation reactive oxygen species antioxidant |
author_facet |
Candice G. T. Tahimic Ruth K. Globus |
author_sort |
Candice G. T. Tahimic |
title |
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight |
title_short |
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight |
title_full |
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight |
title_fullStr |
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight |
title_full_unstemmed |
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight |
title_sort |
redox signaling and its impact on skeletal and vascular responses to spaceflight |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-10-01 |
description |
Spaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculature at the level of the whole organism. Recent experiments from spaceflight and ground-based models have provided fresh insights into how these environmental stresses influence mechanisms that are related to redox signaling, oxidative stress, and tissue dysfunction. Emerging mechanistic knowledge on cellular defenses to radiation and other environmental stressors, including microgravity, are useful for both screening and developing interventions against spaceflight-induced deficits in bone and vascular function. |
topic |
spaceflight bone vasculature oxidative stress microgravity hindlimb unloading radiation reactive oxygen species antioxidant |
url |
https://www.mdpi.com/1422-0067/18/10/2153 |
work_keys_str_mv |
AT candicegttahimic redoxsignalinganditsimpactonskeletalandvascularresponsestospaceflight AT ruthkglobus redoxsignalinganditsimpactonskeletalandvascularresponsestospaceflight |
_version_ |
1716824657070391296 |