Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

Abstract Background Aβ1-42 peptide abnormal production is associated with the development and maintenance of neuroinflammation and oxidative stress in brains from Alzheimer disease (AD) patients. Suppression of neuroinflammation may then represent a suitable therapeutic target in AD. We evaluated th...

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Bibliographic Details
Main Authors:	Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo, Luigi M. Grimaldi
Format:	Article
Language:	English
Published:	BMC 2019-02-01
Series:	Journal of Neuroinflammation
Subjects:	IFNβ1a Neuroinflammation ROS Pro-inflammatory cytokines SOD Aβ1-42
Online Access:	http://link.springer.com/article/10.1186/s12974-019-1417-4

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