Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function
Abstract Background Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study. Methods All the recr...
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doaj-1f8f776a7f7c4e45bd6a0338a7c484802020-11-24T21:38:49ZengBMCEnvironmental Health and Preventive Medicine1342-078X1347-47152017-05-012211810.1186/s12199-017-0660-5Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal functionRishila Ghosh0Manushi Siddarth1Neeru Singh2Vipin Tyagi3Pawan Kumar Kare4Basu Dev Banerjee5Om Prakash Kalra6Ashok Kumar Tripathi7Department of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalMultidisciplinary Research Unit, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Medicine, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalDepartment of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. HospitalAbstract Background Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study. Methods All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100). Blood OCP levels of all three study groups were analyzed by gas chromatography. Results Increased level of OCPs, namely α-HCH, aldrin, and β-endosulfan, were observed in CKDu patients as compared to healthy control and CKD patients of known etiology. The levels of these pesticides significantly correlated negatively with the estimated glomerular filtration rate (eGFR) and positively with urinary albumin of CKD patients. Logistic regression analysis revealed association of γ-HCH, p, p′-DDE, and β-endosulfan with CKDu on adjustment of age, sex, BMI, and total lipid content. Conclusions Increased blood level of certain organochlorine pesticides is associated with the development of chronic kidney disease of unknown etiology.http://link.springer.com/article/10.1186/s12199-017-0660-5Organochlorine pesticidesChronic kidney disease of unknown etiologyeGFRUrinary albumin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rishila Ghosh Manushi Siddarth Neeru Singh Vipin Tyagi Pawan Kumar Kare Basu Dev Banerjee Om Prakash Kalra Ashok Kumar Tripathi |
spellingShingle |
Rishila Ghosh Manushi Siddarth Neeru Singh Vipin Tyagi Pawan Kumar Kare Basu Dev Banerjee Om Prakash Kalra Ashok Kumar Tripathi Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function Environmental Health and Preventive Medicine Organochlorine pesticides Chronic kidney disease of unknown etiology eGFR Urinary albumin |
author_facet |
Rishila Ghosh Manushi Siddarth Neeru Singh Vipin Tyagi Pawan Kumar Kare Basu Dev Banerjee Om Prakash Kalra Ashok Kumar Tripathi |
author_sort |
Rishila Ghosh |
title |
Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
title_short |
Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
title_full |
Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
title_fullStr |
Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
title_full_unstemmed |
Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
title_sort |
organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function |
publisher |
BMC |
series |
Environmental Health and Preventive Medicine |
issn |
1342-078X 1347-4715 |
publishDate |
2017-05-01 |
description |
Abstract Background Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study. Methods All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100). Blood OCP levels of all three study groups were analyzed by gas chromatography. Results Increased level of OCPs, namely α-HCH, aldrin, and β-endosulfan, were observed in CKDu patients as compared to healthy control and CKD patients of known etiology. The levels of these pesticides significantly correlated negatively with the estimated glomerular filtration rate (eGFR) and positively with urinary albumin of CKD patients. Logistic regression analysis revealed association of γ-HCH, p, p′-DDE, and β-endosulfan with CKDu on adjustment of age, sex, BMI, and total lipid content. Conclusions Increased blood level of certain organochlorine pesticides is associated with the development of chronic kidney disease of unknown etiology. |
topic |
Organochlorine pesticides Chronic kidney disease of unknown etiology eGFR Urinary albumin |
url |
http://link.springer.com/article/10.1186/s12199-017-0660-5 |
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