Direct Fibrinolytic Snake Venom Metalloproteinases Affecting Hemostasis: Structural, Biochemical Features and Therapeutic Potential

Direct Fibrinolytic Snake Venom Metalloproteinases Affecting Hemostasis: Structural, Biochemical Features and Therapeutic Potential

Snake venom metalloproteinases (SVMPs) are predominant in viperid venoms, which provoke hemorrhage and affect hemostasis and thrombosis. P-I class enzymes consist only of a single metalloproteinase domain. Despite sharing high sequence homology, only some of them induce hemorrhage. They have direct...

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Bibliographic Details
Main Authors: Eladio F. Sanchez, Renzo J. Flores-Ortiz, Valeria G. Alvarenga, Johannes A. Eble
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Toxins
Subjects:
metalloproteinases
animal toxins
thrombolysis
antithrombotics
Online Access:https://www.mdpi.com/2072-6651/9/12/392

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