Naturally Occurring Cinnamic Acid Sugar Ester Derivatives
Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great...
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doaj-1f9430f66bbc4f6b90108651bc1207962020-11-24T22:32:56ZengMDPI AGMolecules1420-30492016-10-012110140210.3390/molecules21101402molecules21101402Naturally Occurring Cinnamic Acid Sugar Ester DerivativesYuxin Tian0Weirui Liu1Yi Lu2Yan Wang3Xiaoyi Chen4Shaojuan Bai5Yicheng Zhao6Ting He7Fengxue Lao8Yinghui Shang9Yu Guo10Gaimei She11School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaCinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3′,6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.http://www.mdpi.com/1420-3049/21/10/1402cinnamic acid sugar ester derivativesphytochemistrypharmacological activitytraditional Chinese medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuxin Tian Weirui Liu Yi Lu Yan Wang Xiaoyi Chen Shaojuan Bai Yicheng Zhao Ting He Fengxue Lao Yinghui Shang Yu Guo Gaimei She |
spellingShingle |
Yuxin Tian Weirui Liu Yi Lu Yan Wang Xiaoyi Chen Shaojuan Bai Yicheng Zhao Ting He Fengxue Lao Yinghui Shang Yu Guo Gaimei She Naturally Occurring Cinnamic Acid Sugar Ester Derivatives Molecules cinnamic acid sugar ester derivatives phytochemistry pharmacological activity traditional Chinese medicine |
author_facet |
Yuxin Tian Weirui Liu Yi Lu Yan Wang Xiaoyi Chen Shaojuan Bai Yicheng Zhao Ting He Fengxue Lao Yinghui Shang Yu Guo Gaimei She |
author_sort |
Yuxin Tian |
title |
Naturally Occurring Cinnamic Acid Sugar Ester Derivatives |
title_short |
Naturally Occurring Cinnamic Acid Sugar Ester Derivatives |
title_full |
Naturally Occurring Cinnamic Acid Sugar Ester Derivatives |
title_fullStr |
Naturally Occurring Cinnamic Acid Sugar Ester Derivatives |
title_full_unstemmed |
Naturally Occurring Cinnamic Acid Sugar Ester Derivatives |
title_sort |
naturally occurring cinnamic acid sugar ester derivatives |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-10-01 |
description |
Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3′,6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds. |
topic |
cinnamic acid sugar ester derivatives phytochemistry pharmacological activity traditional Chinese medicine |
url |
http://www.mdpi.com/1420-3049/21/10/1402 |
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