Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogen...

Full description

Bibliographic Details
Main Authors: Yong-Xin Li, Zheng Zhong, Wei-Peng Zhang, Pei-Yuan Qian
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05781-6
id doaj-1f977197bcd24fb09fdce82c6abb4807
record_format Article
spelling doaj-1f977197bcd24fb09fdce82c6abb48072021-05-11T09:26:14ZengNature Publishing GroupNature Communications2041-17232018-08-01911910.1038/s41467-018-05781-6Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome miningYong-Xin Li0Zheng Zhong1Wei-Peng Zhang2Pei-Yuan Qian3Department of Ocean Science and Division of Life Science, Hong Kong University of Science and TechnologyDepartment of Ocean Science and Division of Life Science, Hong Kong University of Science and TechnologyDepartment of Ocean Science and Division of Life Science, Hong Kong University of Science and TechnologyDepartment of Ocean Science and Division of Life Science, Hong Kong University of Science and TechnologyMicrobial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.https://doi.org/10.1038/s41467-018-05781-6
collection DOAJ
language English
format Article
sources DOAJ
author Yong-Xin Li
Zheng Zhong
Wei-Peng Zhang
Pei-Yuan Qian
spellingShingle Yong-Xin Li
Zheng Zhong
Wei-Peng Zhang
Pei-Yuan Qian
Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
Nature Communications
author_facet Yong-Xin Li
Zheng Zhong
Wei-Peng Zhang
Pei-Yuan Qian
author_sort Yong-Xin Li
title Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_short Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_full Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_fullStr Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_full_unstemmed Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_sort discovery of cationic nonribosomal peptides as gram-negative antibiotics through global genome mining
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.
url https://doi.org/10.1038/s41467-018-05781-6
work_keys_str_mv AT yongxinli discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining
AT zhengzhong discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining
AT weipengzhang discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining
AT peiyuanqian discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining
_version_ 1721449851741274112

Similar Items