Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man
BackgroundWave intensity analysis provides valuable information on ventriculo-arterial function, hemodynamics, and energy transfer in the arterial circulation. Widespread use of wave intensity analysis is limited by the need for concurrent measurement of pressure and flow waveforms. We describe a me...
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doaj-1f9abce190af4b23a5c0cb13babb34f62020-11-25T03:22:53ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-05-011110.3389/fphys.2020.00550525300Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in ManAlun D. Hughes0Chloe Park1Anenta Ramakrishnan2Anenta Ramakrishnan3Jamil Mayet4Nish Chaturvedi5Kim H. Parker6Medical Research Council Unit for Lifelong Health and Ageing at UCL, Department of Population Science & Experimental Medicine, Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, United KingdomMedical Research Council Unit for Lifelong Health and Ageing at UCL, Department of Population Science & Experimental Medicine, Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, United KingdomCardiovascular Division, Faculty of Medicine, Imperial College London, National Heart & Lung Institute, London, United KingdomDepartment of Bioengineering, Imperial College London, London, United KingdomCardiovascular Division, Faculty of Medicine, Imperial College London, National Heart & Lung Institute, London, United KingdomMedical Research Council Unit for Lifelong Health and Ageing at UCL, Department of Population Science & Experimental Medicine, Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, United KingdomDepartment of Bioengineering, Imperial College London, London, United KingdomBackgroundWave intensity analysis provides valuable information on ventriculo-arterial function, hemodynamics, and energy transfer in the arterial circulation. Widespread use of wave intensity analysis is limited by the need for concurrent measurement of pressure and flow waveforms. We describe a method that can estimate wave intensity patterns using only non-invasive pressure waveforms (pWIA).MethodsRadial artery pressure and left ventricular outflow tract (LVOT) flow velocity waveforms were recorded in 12 participants in the Southall and Brent Revisited (SABRE) study. Pressure waveforms were analyzed using custom-written software to derive the excess pressure (Pxs) which was scaled to peak LVOT velocity and used to calculate wave intensity. These data were compared with wave intensity calculated using the measured LVOT flow velocity waveform. In a separate study, repeat measures of pWIA were performed on 34 individuals who attended two clinic visits at an interval of ≈1 month to assess reproducibility and reliability of the method.ResultsPxs waveforms were similar in shape to aortic flow velocity waveforms and the time of peak Pxs and peak aortic velocity agreed closely. Wave intensity estimated using pWIA showed acceptable agreement with estimates using LVOT velocity tracings and estimates of wave intensity were similar to values reported previously in the literature. The method showed fair to good reproducibility for most parameters.ConclusionThe Pxs is a surrogate of LVOT flow velocity which, when appropriately scaled, allows estimation of aortic wave intensity with acceptable reproducibility. This may enable wider application of wave intensity analysis to large studies.https://www.frontiersin.org/article/10.3389/fphys.2020.00550/fullblood pressurehemodynamicswaveswave intensity analysisblood flowaorta |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alun D. Hughes Chloe Park Anenta Ramakrishnan Anenta Ramakrishnan Jamil Mayet Nish Chaturvedi Kim H. Parker |
spellingShingle |
Alun D. Hughes Chloe Park Anenta Ramakrishnan Anenta Ramakrishnan Jamil Mayet Nish Chaturvedi Kim H. Parker Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man Frontiers in Physiology blood pressure hemodynamics waves wave intensity analysis blood flow aorta |
author_facet |
Alun D. Hughes Chloe Park Anenta Ramakrishnan Anenta Ramakrishnan Jamil Mayet Nish Chaturvedi Kim H. Parker |
author_sort |
Alun D. Hughes |
title |
Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man |
title_short |
Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man |
title_full |
Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man |
title_fullStr |
Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man |
title_full_unstemmed |
Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man |
title_sort |
feasibility of estimation of aortic wave intensity using non-invasive pressure recordings in the absence of flow velocity in man |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-05-01 |
description |
BackgroundWave intensity analysis provides valuable information on ventriculo-arterial function, hemodynamics, and energy transfer in the arterial circulation. Widespread use of wave intensity analysis is limited by the need for concurrent measurement of pressure and flow waveforms. We describe a method that can estimate wave intensity patterns using only non-invasive pressure waveforms (pWIA).MethodsRadial artery pressure and left ventricular outflow tract (LVOT) flow velocity waveforms were recorded in 12 participants in the Southall and Brent Revisited (SABRE) study. Pressure waveforms were analyzed using custom-written software to derive the excess pressure (Pxs) which was scaled to peak LVOT velocity and used to calculate wave intensity. These data were compared with wave intensity calculated using the measured LVOT flow velocity waveform. In a separate study, repeat measures of pWIA were performed on 34 individuals who attended two clinic visits at an interval of ≈1 month to assess reproducibility and reliability of the method.ResultsPxs waveforms were similar in shape to aortic flow velocity waveforms and the time of peak Pxs and peak aortic velocity agreed closely. Wave intensity estimated using pWIA showed acceptable agreement with estimates using LVOT velocity tracings and estimates of wave intensity were similar to values reported previously in the literature. The method showed fair to good reproducibility for most parameters.ConclusionThe Pxs is a surrogate of LVOT flow velocity which, when appropriately scaled, allows estimation of aortic wave intensity with acceptable reproducibility. This may enable wider application of wave intensity analysis to large studies. |
topic |
blood pressure hemodynamics waves wave intensity analysis blood flow aorta |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.00550/full |
work_keys_str_mv |
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