Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

In our study, we attempted to investigate the influences of P-glycoprotein (P-gp) on DL0410, a novel synthetic molecule for Alzheimer’s disease (AD) treatment, for intestinal absorption and blood-brain barrier permeability in vitro and related binding mechanisms in silico. Caco-2, MDCK, and MDCK-MDR...

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Bibliographic Details
Main Authors:	Xiaocong Pang, Lin Wang, De Kang, Ying Zhao, Song Wu, Ai-Lin Liu, Guan-Hua Du
Format:	Article
Language:	English
Published:	MDPI AG 2017-07-01
Series:	Molecules
Subjects:	Alzheimer’s disease DL0410 P-glycoprotein homology modelling molecular docking
Online Access:	https://www.mdpi.com/1420-3049/22/8/1246

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