A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive cru...

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Main Authors: Aline Maria de Vita-Marques, Simone P. Lira, Roberto G. S. Berlinck, Mirna H. R. Seleghim, Sandra R. P. Sponchiado, Sâmia M. Tauk-Tornisielo, Margarida Barata, Claudia Pessoa, Manoel O. de Moraes, Bruno Coêlho Cavalcanti, Gislene G. F. Nascimento, Ana O. de Souza, Fabio C. S. Galetti, Célio L. Silva, Marcio Silva, Eli F. Pimenta, Otavio Thiemann, Michel R. Z. Passarini, Lara D. Sette
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2008-01-01
Series:Química Nova
Subjects:
marine-derived fungi
screening
Beauveria felina
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500030
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spelling doaj-1fac4903804047d2a29b914f0812429d2020-11-24T22:12:49ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642008-01-013151099110310.1590/S0100-40422008000500030A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felinaAline Maria de Vita-MarquesSimone P. LiraRoberto G. S. BerlinckMirna H. R. SeleghimSandra R. P. SponchiadoSâmia M. Tauk-TornisieloMargarida BarataClaudia PessoaManoel O. de MoraesBruno Coêlho CavalcantiGislene G. F. NascimentoAna O. de SouzaFabio C. S. GalettiCélio L. SilvaMarcio SilvaEli F. PimentaOtavio ThiemannMichel R. Z. PassariniLara D. SetteExtracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500030marine-derived fungiscreeningBeauveria felina
collection DOAJ
language English
format Article
sources DOAJ
author Aline Maria de Vita-Marques
Simone P. Lira
Roberto G. S. Berlinck
Mirna H. R. Seleghim
Sandra R. P. Sponchiado
Sâmia M. Tauk-Tornisielo
Margarida Barata
Claudia Pessoa
Manoel O. de Moraes
Bruno Coêlho Cavalcanti
Gislene G. F. Nascimento
Ana O. de Souza
Fabio C. S. Galetti
Célio L. Silva
Marcio Silva
Eli F. Pimenta
Otavio Thiemann
Michel R. Z. Passarini
Lara D. Sette
spellingShingle Aline Maria de Vita-Marques
Simone P. Lira
Roberto G. S. Berlinck
Mirna H. R. Seleghim
Sandra R. P. Sponchiado
Sâmia M. Tauk-Tornisielo
Margarida Barata
Claudia Pessoa
Manoel O. de Moraes
Bruno Coêlho Cavalcanti
Gislene G. F. Nascimento
Ana O. de Souza
Fabio C. S. Galetti
Célio L. Silva
Marcio Silva
Eli F. Pimenta
Otavio Thiemann
Michel R. Z. Passarini
Lara D. Sette
A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
Química Nova
marine-derived fungi
screening
Beauveria felina
author_facet Aline Maria de Vita-Marques
Simone P. Lira
Roberto G. S. Berlinck
Mirna H. R. Seleghim
Sandra R. P. Sponchiado
Sâmia M. Tauk-Tornisielo
Margarida Barata
Claudia Pessoa
Manoel O. de Moraes
Bruno Coêlho Cavalcanti
Gislene G. F. Nascimento
Ana O. de Souza
Fabio C. S. Galetti
Célio L. Silva
Marcio Silva
Eli F. Pimenta
Otavio Thiemann
Michel R. Z. Passarini
Lara D. Sette
author_sort Aline Maria de Vita-Marques
title A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_short A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_full A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_fullStr A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_full_unstemmed A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_sort multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from beauveria felina
publisher Sociedade Brasileira de Química
series Química Nova
issn 0100-4042
1678-7064
publishDate 2008-01-01
description Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
topic marine-derived fungi
screening
Beauveria felina
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500030
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