Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents
Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to heal...
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Wolters Kluwer Medknow Publications
2021-01-01
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doaj-1fada05f22e74e6586e1576dbcae211e2021-07-27T04:48:59ZengWolters Kluwer Medknow PublicationsNeurological Sciences and Neurophysiology2636-865X2021-01-01382909610.4103/NSN.NSN_94_20Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and AdolescentsHasan TekgulUlas SazMuzaffer PolatNurdan TekgulTimur KoseContext: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean ± standard deviation age: 6.4 ± 1.2 years; range: 3.0–20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents.http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgulicentral motor conduction timecorticospinal pathwayslatency jumpingmotor evoked potentialstranscranial magnetic stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose |
spellingShingle |
Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents Neurological Sciences and Neurophysiology icentral motor conduction time corticospinal pathways latency jumping motor evoked potentials transcranial magnetic stimulation |
author_facet |
Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose |
author_sort |
Hasan Tekgul |
title |
Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
title_short |
Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
title_full |
Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
title_fullStr |
Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
title_full_unstemmed |
Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
title_sort |
normative values of transcranial magnetic stimulation-evoked parameters for healthy developing children and adolescents |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neurological Sciences and Neurophysiology |
issn |
2636-865X |
publishDate |
2021-01-01 |
description |
Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean ± standard deviation age: 6.4 ± 1.2 years; range: 3.0–20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents. |
topic |
icentral motor conduction time corticospinal pathways latency jumping motor evoked potentials transcranial magnetic stimulation |
url |
http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgul |
work_keys_str_mv |
AT hasantekgul normativevaluesoftranscranialmagneticstimulationevokedparametersforhealthydevelopingchildrenandadolescents AT ulassaz normativevaluesoftranscranialmagneticstimulationevokedparametersforhealthydevelopingchildrenandadolescents AT muzafferpolat normativevaluesoftranscranialmagneticstimulationevokedparametersforhealthydevelopingchildrenandadolescents AT nurdantekgul normativevaluesoftranscranialmagneticstimulationevokedparametersforhealthydevelopingchildrenandadolescents AT timurkose normativevaluesoftranscranialmagneticstimulationevokedparametersforhealthydevelopingchildrenandadolescents |
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