Impact of REM sleep deprivation and sleep recovery on circulatory neuroinflammatory markers
Objectives: Sleep loss may contribute to neuroinflammation, which might increase neuroinflammatory markers such as neuron-specific enolase (NSE), creatine kinase-brain fraction (CK-BB), lactate dehydrogenase brain fraction (LDH-BB) in blood. Hence, we evaluated the effect...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Brazilian Association of Sleep and Latin American Federation of Sleep Societies
2021-03-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | https://sleepscience.org.br/export-pdf/2912/v14n1a10.pdf |
| Summary: | Objectives: Sleep loss may contribute to neuroinflammation, which might increase
neuroinflammatory markers such as neuron-specific enolase (NSE), creatine kinase-brain fraction
(CK-BB), lactate dehydrogenase brain fraction (LDH-BB) in blood. Hence, we evaluated the effect
of REM sleep deprivation and recovery on these markers. Material and Methods: Twenty-four
adult male Sprague Dawley rats were grouped as control, environmental control, REM sleep
deprivation, and 24 hour sleep recovery. The rats were sleep deprived for 72 hours and recovered for
24 hours. NSE, CK-BB, and LDH-BB levels in serum were measured using ELISA. Results: The
serum NSE, CK-BB, and LDH-BB were significantly higher in 72 hour sleep deprived group
compared to control (p<0.01). After 24 hours of sleep recovery, the levels of NSE, CK-BB, and
LDH-BB were comparable to control (p>0.05). Discussion: REM sleep deprivation increased
serum NSE, CK-BB, and LDH-BB, which might be due to neural damage. However, 24 hours of
sleep recovery restored these markers. |
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| ISSN: | 1984-0659 1984-0063 |