Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis

• Main Authors: Stevanovic G., Pelemis M., Pelemis S., Pavlovic M.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2012-01-01
• Series: Archives of Biological Sciences
• Subjects: Tuberculosis; adenosine deaminase; immunoglobulin G; fever of unknown origin; laboratory tests
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641202489S.pdf

Serum concentrations of adenosine deaminase were determined in 223 febrile patients. In 62, we discovered extrapulmonary tuberculosis. Serum levels of immunoglobulin G were monitored in 287 febrile patients, and 68 had extra-pulmonary tuberculosis. Serum concentrations of adenosine deaminase were significantly higher in patients with tuberculosis compared to other patients with fever of unknown origin. Serum concentrations declined during antituberculosis therapy. A correlation with the localization of infection was not found. Levels of immunoglobulin G were higher in patients with tuberculosis. Both tests had high sensitivity and specificity and could therefore be used for screening extrapulmonary tuberculosis; however, they can only be interpreted adequately following a full clinical investigation.