First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy.
Successful control of the HIV/AIDS pandemic requires reduction of HIV-1 transmission at sexually-exposed mucosae. No prevention studies of the higher-risk rectal compartment exist. We report the first-in-field Phase 1 trial of a rectally-applied, vaginally-formulated microbicide gel with the RT-inhi...
Main Authors: | Peter A Anton, Terry Saunders, Julie Elliott, Elena Khanukhova, Robert Dennis, Amy Adler, Galen Cortina, Karen Tanner, John Boscardin, William G Cumberland, Ying Zhou, Ana Ventuneac, Alex Carballo-Diéguez, Lorna Rabe, Timothy McCormick, Henry Gabelnick, Christine Mauck, Ian McGowan |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3182160?pdf=render |
Similar Items
-
Microbicides 2006 conference
by: McGowan Ian, et al.
Published: (2006-10-01) -
Tuning the Engine Skoda 781 for Sport Competitions
by: Ragan Branislav, et al.
Published: (2014-12-01) -
Use of commercial rectal lubricants among MSM: lessons for rectal microbicides
by: A. Carballo-Diéguez, et al.
Published: (2016-05-01) -
Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation.
by: Charlene S Dezzutti, et al.
Published: (2014-01-01) -
781 Validation of the combinatorial effect of blinatumomab and nivolumab in cancer therapy
by: Jie Zhang, et al.
Published: (2020-11-01)