Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine?
Abstract Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients according to their disease subgroup and predicted response to treatment. The EULAR...
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Online Access: | http://link.springer.com/article/10.1186/s13075-019-1871-5 |
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doaj-1fb6cca3e8b5461097e12a056b9a1e112020-11-25T02:10:47ZengBMCArthritis Research & Therapy1478-63622019-04-012111210.1186/s13075-019-1871-5Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine?Helen Michelle McGettrick0Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of BirminghamAbstract Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients according to their disease subgroup and predicted response to treatment. The EULAR Synovitis Study Group and the OMERACT synovial tissue biopsy (STB) Special Interests Group have undertaken a consensus exercise to identify factors that are important for the standardisation of STB handling and analytical procedures in two situations—clinical practice and translational research.http://link.springer.com/article/10.1186/s13075-019-1871-5Synovial biopsyRheumatoid arthritisSynovial tissue analysisStandardisationFibroblastSTB |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Helen Michelle McGettrick |
spellingShingle |
Helen Michelle McGettrick Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? Arthritis Research & Therapy Synovial biopsy Rheumatoid arthritis Synovial tissue analysis Standardisation Fibroblast STB |
author_facet |
Helen Michelle McGettrick |
author_sort |
Helen Michelle McGettrick |
title |
Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
title_short |
Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
title_full |
Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
title_fullStr |
Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
title_full_unstemmed |
Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
title_sort |
synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine? |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2019-04-01 |
description |
Abstract Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients according to their disease subgroup and predicted response to treatment. The EULAR Synovitis Study Group and the OMERACT synovial tissue biopsy (STB) Special Interests Group have undertaken a consensus exercise to identify factors that are important for the standardisation of STB handling and analytical procedures in two situations—clinical practice and translational research. |
topic |
Synovial biopsy Rheumatoid arthritis Synovial tissue analysis Standardisation Fibroblast STB |
url |
http://link.springer.com/article/10.1186/s13075-019-1871-5 |
work_keys_str_mv |
AT helenmichellemcgettrick synovialtissuebiopsyanalysisunlockingthehiddensecretstopersonalisedmedicine |
_version_ |
1724917445264670720 |