Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes
Cardiac Troponin I (cTnI) is a subunit of the thin filament involved in regulation of heart contraction. Mutated cTnI accounts for most genetic mutations associated with restrictive cardiomyopathy (RCM). We previously found phosphodiesterase 4D (PDE4D) decreased in RCM mice with cTnIR193H mutation a...
Main Authors: | Weian Zhao, Qian lu, Jing Luo, Bo Pan, Ling-Juan Liu, Jie Tian |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-07-01
|
Series: | Genes and Diseases |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S235230422030012X |
Similar Items
-
Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
by: Elizabeth A. Thomas
Published: (2014-05-01) -
HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action
by: Yoichi Imai, et al.
Published: (2019-04-01) -
HDAC3 and HDAC8 are required for cilia assembly and elongation
by: Seon-ah Park, et al.
Published: (2019-08-01) -
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
by: Guo Li, et al.
Published: (2020-09-01) -
Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy
by: Gloria Manzotti, et al.
Published: (2019-03-01)