Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death

Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death

The growth factor Flt3 ligand (Flt3L) is central to dendritic cell (DC) homeostasis and development, controlling survival and expansion by binding to Flt3 receptor tyrosine kinase on the surface of DCs. In the context of hematopoietic cell transplantation, Flt3L has been found to suppress graft-vers...

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Bibliographic Details
Main Authors: Megan S. Molina, Emely A. Hoffman, Jessica Stokes, Nicole Kummet, Kyle A. Smith, Forrest Baker, Tiffany M. Zúñiga, Richard J. Simpson, Emmanuel Katsanis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
Flt3
bendamustine
Alloreactivity
Regulatory DC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.699128/full

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