Localisation of clozapine during experimental autoimmune encephalomyelitis and its impact on dopamine and its receptors
Abstract Multiple sclerosis is a disease characterised by axonal demyelination in the central nervous system (CNS). The atypical antipsychotic drug clozapine attenuates experimental autoimmune encephalomyelitis (EAE), a mouse model used to study multiple sclerosis, but the precise mechanism is unkno...
Main Authors: | Katharina Robichon, Sven Sondhauss, T. William Jordan, Robert A. Keyzers, Bronwen Connor, Anne C. La Flamme |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-82667-6 |
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