JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head. However, pathological signaling pathways that exert central roles in...

Full description

Bibliographic Details
Main Authors: Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Neurobiology of Disease
Subjects:
JNK
Axonal injury
Apoptosis
Retinal ganglion cell
cJUN
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000459

Similar Items

Similar Items